ArticleThe journal of nutrition, health & aging2017
Impact of Age on the Association Between Body Mass Index and All-Cause Mortality in Patients with Atrial Fibrillation.
Article in The journal of nutrition, health & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Pooled it
- Low-Dose NOACs Versus Standard-Dose NOACs or Warfarin on Efficacy and Safety in Asian Patients with NVAF: A Meta-Analysis.Anatolian journal of cardiology · 2022Pooled it
- National trends in mortality attributable to arrhythmias among adults with obesity in the United States, 1999-2020.American heart journal plus : cardiology research and practice · 2025Article
- Adulthood weight changes, body mass index in youth, genetic susceptibility and risk of atrial fibrillation: a population-based cohort study.BMC medicine · 2024Article
- Safety and efficacy of direct oral anticoagulants in comparison with warfarin across different BMI ranges: A systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2022Review
- Real-World Comparisons of Low-Dose NOACs versus Standard-Dose NOACs or Warfarin on Efficacy and Safety in Patients with AF: A Meta-Analysis.Cardiology research and practice · 2022Article
- The Association of Subscapular Skinfold with All-Cause, Cardiovascular and Cerebrovascular Mortality.Risk management and healthcare policy · 2020Article
- Body mass index and all-cause mortality in patients with atrial fibrillation: insights from the China atrial fibrillation registry study.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Observational
- Pulse wave velocity is decreased with obesity in an elderly Chinese population.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore the impact of age on the association between body mass index (BMI) and all-cause mortality in patients with atrial fibrillation (AF).
methodsA total of 1991 patients with AF (69 ± 13 years, 54.9% female) were divided into three age groups: < 65 years, 65-75 years, and > 75 years, and followed for one year. The primary outcome was defined as all-cause mortality, with secondary outcomes including thromboembolism and major bleeding. Cox regression models were utilized to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
resultsCompared to patients aged < 65 years, elder groups had much lower BMI and more comorbidities other than a lower prevalence of valvular heart disease. During one-year follow-up, 277 (13.9%) patients died, 158 (7.9%) underwent thromboembolism events and 26 (1.3%) had major bleeding. Mortality and thromboembolism risk were both notably higher in patients with advanced age (all P values < 0.001). Using normal weight patients as reference, mortality risk was significantly lower in overweight (HR 0.548; 95% CI 0.404-0.744) and obese patients (HR 0.536; 95% CI 0.325-0.883) for the entire cohort, with reduced death risk mainly observed in overweight patients aged 65-75 years (HR 0.285; 95% CI 0.131-0.621) and aged > 75 years (HR 0.686; 95% CI 0.473-0.993), but not in patients aged < 65 years. Continuous analyses of BMI indicated consistent results.
conclusionHigh BMI is associated with reduced mortality rate in patients with AF, and this association is affected by age, with the so-called "obesity paradox" confined to those with advanced age rather than young patients.
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