Evidence map›Paper›PMID 29188803›Full record

ArticleActa pharmacologica Sinica2018

Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β

Pedro Martín, Melisa Moncada, Guruprasad Kuntamallappanavar, Alex M Dopico, Verónica Milesi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Calcium- and voltage-gated BK channels in vascular smooth muscle.Pflugers Archiv : European journal of physiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Pedro MartínIIFP, UNLP, CONICET - Instituto de estudios Inmunológicos y Fisiopatológicos, Universidad Nacional de La Plata, Consejo Nacional de Investigaciones Científicas y Tecnológicas, La Plata, Argentina. 47 y 115 S/N, La Plata (1900), Buenos Aires, Argentina.
Melisa MoncadaIIFP, UNLP, CONICET - Instituto de estudios Inmunológicos y Fisiopatológicos, Universidad Nacional de La Plata, Consejo Nacional de Investigaciones Científicas y Tecnológicas, La Plata, Argentina. 47 y 115 S/N, La Plata (1900), Buenos Aires, Argentina.
Guruprasad KuntamallappanavarDepartment of Pharmacology, College of Medicine, The University of Tennessee Health Science Center, 71 South Manassas St, Memphis, TN, 38103, USA.
Alex M DopicoDepartment of Pharmacology, College of Medicine, The University of Tennessee Health Science Center, 71 South Manassas St, Memphis, TN, 38103, USA.
Verónica MilesiIIFP, UNLP, CONICET - Instituto de estudios Inmunológicos y Fisiopatológicos, Universidad Nacional de La Plata, Consejo Nacional de Investigaciones Científicas y Tecnológicas, La Plata, Argentina. 47 y 115 S/N, La Plata (1900), Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of Tennessee Health Science Center · USUniversidad Nacional de La Plata · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiazide-like diuretics are the most commonly used drugs to treat arterial hypertension, with their efficacy being linked to their chronic vasodilatory effect. Previous studies suggest that activation of the large conductance voltage- and Ca

Indexed as

Cells, CulturedHumansHydrochlorothiazideLarge-Conductance Calcium-Activated Potassium Channel beta SubunitsMembrane PotentialsMyocytes, Smooth MuscleHydrochlorothiazideLarge-Conductance Calcium-Activated Potassium Channel beta Subunits

Identifiers

PMID29188803
PMCPMC5843832
OpenAlexW2774274754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.