ArticleCognitive neuropsychology2017
Can neuroimaging help aphasia researchers? Addressing generalizability, variability, and interpretability.
Article in Cognitive neuropsychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- The cerebellar components of the human language network.bioRxiv : the preprint server for biology · 2025Article
- Independent contributions of language activations in left and right temporal cortex to aphasia outcomes after stroke.medRxiv : the preprint server for health sciences · 2025Article
- The language network as a natural kind within the broader landscape of the human brain.Nature reviews. Neuroscience · 2024Review
- CHANGES IN FUNCTIONAL CONNECTIVITY FOLLOWING INTENSIVE ATTENTION TRAINING IN PATIENTS WITH TRAUMATIC BRAIN INJURY. A PILOT STUDY.Journal of rehabilitation medicine. Clinical communications · 2024Article
- The human language system, including its inferior frontal component in "Broca's area," does not support music perception.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Modality-Specificity of the Neural Correlates of Linguistic and Non-Linguistic Demand.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Distinct neural correlates of linguistic demand and non-linguistic demand.Neurobiology of language (Cambridge, Mass.) · 2021Article
- The Language Network Is Recruited but Not Required for Nonverbal Event Semantics.Neurobiology of language (Cambridge, Mass.) · 2021Article
- Comprehension of computer code relies primarily on domain-general executive brain regions.eLife · 2020Article
- Lack of selectivity for syntax relative to word meanings throughout the language network.Cognition · 2020Article
- fMRI reveals language-specific predictive coding during naturalistic sentence comprehension.Neuropsychologia · 2020Article
- Independent contributions of language activations in left and right temporal cortex to aphasia outcomes after stroke.Imaging neuroscience (Cambridge, Mass.)Article
- Theoretical and methodological issues for twenty-first century cognitive neuropsychology.Cognitive neuropsychologyArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
Neuroimaging studies of individuals with brain damage seek to link brain structure and activity to cognitive impairments, spontaneous recovery, or treatment outcomes. To date, such studies have relied on the critical assumption that a given anatomical landmark corresponds to the same functional unit(s) across individuals. However, this assumption is fallacious even across neurologically healthy individuals. Here, we discuss the severe implications of this issue, and argue for an approach that circumvents it, whereby: (i) functional brain regions are defined separately for each subject using fMRI, allowing for inter-individual variability in their precise location; (ii) the response profile of these subject-specific regions are characterized using various other tasks; and (iii) the results are averaged across individuals, guaranteeing generalizabliity. This method harnesses the complementary strengths of single-case studies and group studies, and it eliminates the need for post hoc "reverse inference" from anatomical landmarks back to cognitive operations, thus improving data interpretability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.