Evidence map›Paper›PMID 29188741›Full record

ArticleJournal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses

Adherence to Oral Medications During Maintenance Therapy Among Children and Adolescents With Acute Lymphoblastic Leukemia: A Medication Refill Analysis.

Yelena P Wu, David D Stenehjem, Lauri A Linder, Bin Yu, Bridget Grahmann Parsons, Ryan Mooney, Mark N Fluchel

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07129395 (Optimizing Measurement of Anticoagulation Adherence), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07129395 active not recruitingnot on this map

Optimizing Measurement of Anticoagulation Adherence

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2023 to 2026Enrolled30ConditionsAnticoagulation
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yelena P Wu1 University of Utah, Salt Lake City, UT, USA.
David D Stenehjem1 University of Utah, Salt Lake City, UT, USA.
Lauri A Linder1 University of Utah, Salt Lake City, UT, USA.
Bin Yu1 University of Utah, Salt Lake City, UT, USA.
Bridget Grahmann Parsons1 University of Utah, Salt Lake City, UT, USA.
Ryan Mooney1 University of Utah, Salt Lake City, UT, USA.
Mark N Fluchel1 University of Utah, Salt Lake City, UT, USA.

Funding

University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
Translational Approaches to Melanoma Prevention in Children at High Genetic RiskK07CA196985 · NCI · UNIVERSITY OF UTAH · PI WU, YELENA PING · 2015 to 2019
$682k
Engaging School-Age Children with Cancer in Designing a Symptom Assessment AppK23NR014874 · NINR · UNIVERSITY OF UTAH · PI LINDER, LAURI A · 2014 to 2016
$386k
NCATS NIH HHS UL1 TR001067NCI NIH HHS K07 CA196985NINR NIH HHS K23 NR014874
6 · The paper itself

Abstract

Adherence to oral medications during maintenance therapy is essential for pediatric patients with acute lymphoblastic leukemia. Self-reported or electronic monitoring of adherence indicate suboptimal adherence, particularly among particular sociodemographic groups. This study used medication refill records to examine adherence among a national sample of pediatric patients with acute lymphoblastic leukemia. Patients in a national claims database, aged 0 to 21 years with a diagnosis of acute lymphoblastic leukemia and in the maintenance phase of treatment, were included. Medication possession ratios were used as measures of adherence. Overall adherence and adherence by sociodemographic groups were examined. Adherence rates were 85% for 6-mercaptopurine and 81% for methotrexate. Adherence was poorer among patients 12 years and older. Oral medication adherence rates were suboptimal and similar to or lower than previously documented rates using other methods of assessing adherence. Refill records offer a promising avenue for monitoring adherence. Additional work to identify groups most at-risk for poor adherence is needed. Nurses are well positioned to routinely monitor for medication adherence and to collaborate with the multidisciplinary team to address barriers to adherence.

Indexed as

Medication AdherenceOutcome Assessment, Health CareAdolescentAntineoplastic Combined Chemotherapy ProtocolsChildChild, PreschoolDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansInfantInfant, NewbornInsurance Claim ReviewMaintenance ChemotherapyMaleMercaptopurineMercaptopurineMethotrexateacute lymphoblastic leukemiamaintenance therapyoral medication adherencepediatric cancerrisk factors

Identifiers

PMID29188741
PMCPMC5935503

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.