ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2018
Diagnosing tick-borne encephalitis: a re-evaluation of notified cases.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Detectability of Pathogenic RNA Virus Families in Different Body Sites: A Scoping Review.Viruses · 2026Article
- A rare case of breakthrough tick-borne encephalitis in early adolescence after vaccination with four doses of TBE vaccine.New microbes and new infections · 2026Article
- Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections.Clinical microbiology reviews · 2024Review
- Article
- Clinical and CSF single-cell profiling of post-COVID-19 cognitive impairment.Cell reports. Medicine · 2024Article
- Suspected tick-borne flavivirus meningoencephalomyelitis in dogs from the UK: six cases (2021).The Journal of small animal practice · 2024Article
- Defining the "Correlate(s) of Protection" to tick-borne encephalitis vaccination and infection - key points and outstanding questions.Frontiers in immunology · 2024Review
- Article
- Results of Tick-Borne Encephalitis Virus (TBEV) Diagnostics in an Endemic Area in Southern Germany, 2007 to 2022.Viruses · 2023Article
- Tick-Borne Encephalitis (TBE): From Tick to Pathology.Journal of clinical medicine · 2023Review
- Cross-Reactive Antibodies in Tick-Borne Encephalitis: Case Report and Literature Review.Antibodies (Basel, Switzerland) · 2022Article
- Usage of FTAMicroorganisms · 2022Article
- Neurochemical biomarkers to study CNS effects of COVID-19: A narrative review and synthesis.Journal of neurochemistry · 2021Review
- Evaluation of antibodies in cerebrospinal fluid for the diagnosis of tick-borne encephalitis in dogs.Acta veterinaria Scandinavica · 2021Article
- Free Immunoglobulin Light Chains in Patients with Tick-Borne Encephalitis: Before and after Treatment.Journal of clinical medicine · 2021Article
- Tick-Borne Encephalitis in Auvergne-Rhône-Alpes Region, France, 2017-2018.Emerging infectious diseases · 2019Article
- Epidemiological Characteristics and Spatial Analysis of Tick-Borne Encephalitis in Jilin Province, China.The American journal of tropical medicine and hygiene · 2019Article
- Intrathecal complement activation by the classical pathway in tick-borne encephalitis.Journal of neurovirology · 2019Article
- Preparation and Investigation of Silver Nanoparticle⁻Antibody Bioconjugates for Electrochemical Immunoassay of Tick-Borne Encephalitis.Sensors (Basel, Switzerland) · 2019Article
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We set out to investigate the serological response of TBE virus (TBEV)-specific IgM and IgG antibodies in stored serum and cerebrospinal fluid (CSF) in notified TBE patients, in order to confirm or reject the diagnosis. We applied the ELISA methods used in clinical practice, Enzygnost and Immunozym, and assessed RT-PCR as a diagnostic tool. A total of 173 TBE cases were notified to the Public Health Agency. Samples from 129 patients were eligible for the study. Stored serum samples were found for 111 patients and CSF samples for 88 patients. All serum samples were analyzed with both Enzygnost and Immunozym, as well as an additional 140 control samples. CSF samples, including samples from ten controls, were analyzed with Immunozym. RT-PCR for TBEV was performed on 126 serum, two whole blood, 96 CSF, two feces and four nasopharynx samples. Only two of 111 notified patients lacked detectable TBEV IgM in serum, from whom one sample was RT-PCR positive. According to the ECDC definition, 117/129 (90.7%) of the reported TBE cases were confirmed. Positive RT-PCR results were obtained in eight patients, one from whole blood and eight from serum samples. Four out of eight of the RT-PCR positive patients were TBEV-IgM positive and none had detectable TBEV-specific IgG. All of the tested CSF, feces and nasopharynx samples were RT-PCR-negative. TBEV-specific IgG was detected in 88.4% and IgM in 31.6% of the CSF samples. RT-PCR on serum samples and CSF IgG antibodies can be used as complementary methods in TBE diagnostics, not least early in the disease course.
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