Evidence map›Paper›PMID 29188118›Full record

ArticleBiomedical optics express2017

Common-path phase-sensitive optical coherence tomography provides enhanced phase stability and detection sensitivity for dynamic elastography.

Gongpu Lan, Manmohan Singh, Kirill V Larin, Michael D Twa

Abstract read
In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  4. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gongpu LanSchool of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.
Manmohan SinghBiomedical Engineering, University of Houston, Houston, TX, USA.
Kirill V LarinBiomedical Engineering, University of Houston, Houston, TX, USA.
Michael D TwaSchool of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI LAURA J. FRISHMAN · 1988 to 2026
$16.4M
Optical Coherence Elastography of the CorneaR01EY022362 · NEI · UNIVERSITY OF HOUSTON · PI Salavat R Aglyamov, Kirill V Larin · 2012 to 2026
$6.7M
Optical elastography for assessment of myocardial regenerationR01HL130804 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LARIN, KIRILL V, MARTIN, JAMES F · 2016 to 2019
$2.9M
NEI NIH HHS P30 EY003039NEI NIH HHS P30 EY007551NEI NIH HHS R01 EY022362NHLBI NIH HHS R01 HL130804
6 · The paper itself

Abstract

Phase-sensitive optical coherence elastography (PhS-OCE) is an emerging optical technique to quantify soft-tissue biomechanical properties. We implemented a common-path OCT design to enhance displacement sensitivity and optical phase stability for dynamic elastography imaging. The background phase stability was greater in common-path PhS-OCE (0.24 ± 0.07nm) than conventional PhS-OCE (1.60 ± 0.11μm). The coefficient of variation for surface displacement measurements using conventional PhS-OCE averaged 11% versus 2% for common-path PhS-OCE. Young's modulus estimates showed good precision (95% CIs) for tissue phantoms: 24.96 ± 2.18kPa (1% agar), 49.69 ± 4.87kPa (1.5% agar), and 116.08 ± 12.14kPa (2% agar), respectively. Common-path PhS-OCE effectively reduced the amplitude of background dynamic optical phase instability to a sub-nanometer level, which provided a larger dynamic detection range and higher detection sensitivity for surface displacement measurements than conventional PhS-OCE.

Indexed as

(110.4500) Optical coherence tomography(120.4570) Optical design of instruments(120.5050) Phase measurement(120.7280) Vibration analysis; Elastography(170.3880) Medical and biological imaging

Identifiers

PMID29188118
PMCPMC5695968

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.