Evidence map›Paper›PMID 29188117›Full record

ArticleBiomedical optics express2017

Efficiency enhancement of Raman spectroscopy at long working distance by parabolic reflector.

Yao Tian, Joshua Weiming Su, Jian Ju, Quan Liu

Abstract read
In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yao Tian *School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Dr. 637459, Singapore.
Joshua Weiming Su *School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Dr. 637459, Singapore.
Jian JuSchool of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Dr. 637459, Singapore.
Quan LiuSchool of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Dr. 637459, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Raman spectroscopy is well suited for readily revealing information about bio-samples. As such, this technique has been applied to a wide range of areas, particularly in bio-medical diagnostics. Raman scattering in bio-samples typically has a low signal level due to the nature of inelastic scattering of photons. To achieve a high signal level, usually a high numerical aperture objective is employed. One drawback with these objectives is that their working distance is very short. However, in many cases of clinical diagnostics, a long working distance is preferable. We propose a practical solution to this problem by enhancing the Raman signal using a parabolic reflector. The high signal level is achieved through the large light collection solid angle of the parabolic reflector while the long working distance is ensured by the novel design of our microscope. The enhancement capability of the microscope was demonstrated on four types of samples. Among these samples, we find that this microscope design is most suitable for turbid samples.

Indexed as

(170.5660) Raman spectroscopy(180.0180) Microscopy

Identifiers

PMID29188117
PMCPMC5695967

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.