Evidence map›Paper›PMID 29188111›Full record

ArticleBiomedical optics express2017

Automatic detection of the foveal center in optical coherence tomography.

Bart Liefers, Freerk G Venhuizen, Vivian Schreur, Bram van Ginneken, Carel Hoyng, Sascha Fauser, Thomas Theelen, Clara I Sánchez

Abstract read
In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. The Human Fovea Is Relatively Horizontally Elongated in Infantile Nystagmus.Investigative ophthalmology & visual science · 2025
    Article
  4. Observational
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. [Artificial intelligence in management of macular edema : Opportunities and challenges].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020
    Review
  11. MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2019
    Review
  12. [Deep learning and neuronal networks in ophthalmology : Applications in the field of optical coherence tomography].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2018
    Review
  13. [Screening and management of retinal diseases using digital medicine].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2018
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bart LiefersDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.
Freerk G VenhuizenDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.
Vivian SchreurDepartment of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands.
Bram van GinnekenDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.
Carel HoyngDepartment of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands.
Sascha FauserRoche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Thomas TheelenDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.
Clara I SánchezDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We propose a method for automatic detection of the foveal center in optical coherence tomography (OCT). The method is based on a pixel-wise classification of all pixels in an OCT volume using a fully convolutional neural network (CNN) with dilated convolution filters. The CNN-architecture contains anisotropic dilated filters and a shortcut connection and has been trained using a dynamic training procedure where the network identifies its own relevant training samples. The performance of the proposed method is evaluated on a data set of 400 OCT scans of patients affected by age-related macular degeneration (AMD) at different severity levels. For 391 scans (97.75%) the method identified the foveal center with a distance to a human reference less than 750 μm, with a mean (± SD) distance of 71 μm ± 107 μm. Two independent observers also annotated the foveal center, with a mean distance to the reference of 57 μm ± 84 μm and 56 μm ± 80 μm, respectively. Furthermore, we evaluate variations to the proposed network architecture and training procedure, providing insight in the characteristics that led to the demonstrated performance of the proposed method.

Indexed as

(100.2960) Image analysis(100.4996) Pattern recognition, neural networks(110.4500) Optical coherence tomography(170.1610) Clinical applications(170.4470) Ophthalmology

Identifiers

PMID29188111
PMCPMC5695961

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.