ArticleBiomedical optics express2017
Non-invasive assessment of human cone photoreceptor function.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 76 citations in OpenAlex.
- Proto-clinical optoretinography dependence on temporal and spatial resolution.Biomedical optics express · 2026Article
- In vivo elastography of the human retina using light-evoked intrinsic actuation.bioRxiv : the preprint server for biology · 2026Article
- Phase-based optoretinographic measurements of cones with a raster-scanning adaptive optics OCT are highly repeatable.Biomedical optics express · 2026Article
- Automated montaging and contrast stretching of adaptive optics ophthalmoscope images.Biomedical optics express · 2026Article
- Evaluating Human Rod Photoreceptor Function Using Pixelwise Intensity-Based Optoretinography.Translational vision science & technology · 2026Article
- ƒ(Cell): Software for Reproducible Analysis of Optoretinograms.Translational vision science & technology · 2026Article
- Refractive adaptive optics scanning light ophthalmoscope with fast 2D MEMS scanner.Biomedical optics express · 2026Article
- Influence of retinal eccentricity, color blindness, and age on optoretinography measured with AOSLO.Biomedical optics express · 2025Article
- Roadmap on advances in visual and physiological optics.Journal of optics (2010) · 2025Review
- Recent Developments in Photoreceptor Optoretinography and Progress Toward Clinical Use.Translational vision science & technology · 2025Review
- Integrated fixation and stimulus channel for adaptive optics ophthalmoscopy.Biomedical optics express · 2025Article
- On the physiological processes underlying optoretinography [Invited].Biomedical optics express · 2025Review
- Longitudinal Changes in Optoretinography Provide an Early and Sensitive Biomarker of Outer Retinal Disease.American journal of ophthalmology · 2025Article
- How early can we detect diabetic retinopathy? A narrative review of imaging tools for structural assessment of the retina.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- The Cone Optoretinogram as a Function of Retinal Eccentricity.Photonics · 2025Article
- Combined optical coherence tomography and electroretinography system for imaging neurovascular coupling in the human retina.Neurophotonics · 2025Article
- Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli.Science advances · 2025Article
- Changes in Waveguiding Cone Photoreceptors and Color Vision in Patients With Diabetes Mellitus.Investigative ophthalmology & visual science · 2024Article
- Parafoveal cone function in choroideremia assessed with adaptive optics optoretinography.Scientific reports · 2024Article
- Intensity-based optoretinography reveals sub-clinical deficits in cone function in retinitis pigmentosa.Frontiers in ophthalmology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Vision begins when light isomerizes the photopigments within photoreceptors. Noninvasive cellular-scale observation of the structure of the human photoreceptor mosaic is made possible through the use of adaptive optics (AO) enhanced ophthalmoscopes, but establishing noninvasive objective measures of photoreceptor function on a similar scale has been more difficult. AO ophthalmoscope images acquired with near-infrared light show that individual cone photoreceptor reflectance can change in response to a visible stimulus. Here we show that the intrinsic response depends on stimulus wavelength and intensity, and that its action spectrum is well-matched to the spectral sensitivity of cone-mediated vision. Our results demonstrate that the cone reflectance response is mediated by photoisomerization, thus making it a direct measure of photoreceptor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.