Evidence map›Paper›PMID 29187929›Full record

ArticleThe Pan African medical journal2017

[Role of GeneXpert MTB/RIF test in the screening for pulmonary tuberculosis at the General Referral Provincial Hospital of Bukavu, in the East of the Democratic Republic of the Congo: balance after 10 months of use].

David Lupande, David Kaishusha, Carine Mihigo, Moise Itongwa, Gustave Yenga, Philippe Katchunga

Open access · goldAbstract readComparative StudyValidation Study
In one paragraph

Article in The Pan African medical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

David LupandeDépartement de Biologie Médicale, Service de Microbiologie/Hôpital Provincial Général de Référence de Bukavu, Université Catholique de Bukavu, B.P 285, Bukavu, RD Congo.
David KaishushaInstitut Supérieur de Techniques Médicales de Nyangezi, Sud-Kivu, RD Congo.
Carine MihigoInstitut Supérieur de Techniques Médicales de Nyangezi, Sud-Kivu, RD Congo.
Moise ItongwaDépartement de Biologie Médicale, Service de Microbiologie/Hôpital Provincial Général de Référence de Bukavu, Université Catholique de Bukavu, B.P 285, Bukavu, RD Congo.
Gustave YengaInstitut Supérieur de Techniques Médicales de Nyangezi, Sud-Kivu, RD Congo.
Philippe KatchungaInstitut Supérieur de Techniques Médicales de Nyangezi, Sud-Kivu, RD Congo.
Institut Supérieur de Technique Médicale · CDUniversité Catholique de Bukavu · CDUniversity of Kinshasa · CD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn sub-Saharan Africa, diagnostic methods for tuberculosis are inadequate and are essentially based on microscopy. They constitute a real obstacle to the control of tuberculosis. This study aimed to evaluate the performance of GeneXpert MTB/RIF test compared to classical Ziehl-Neelsen staining at the the general referral provincial hospital of Bukavu, in the east of the Democratic Republic of the Congo after 10 months of use.

methodsThe results of Ziehl-Neelsen staining and GeneXpert MTB/RIF molecular biology test performed in 452 patients with suspected tuberculosis were collected. This study compares the validity of these different diagnostic tests in the detection of tuberculosis.

resultsIn the entire group, the frequency of the pulmonary tuberculosis was 16.3%. The positivity rate was significantly higher in GeneXpert MTB/RIF test than in Ziehl-Neelsen staining in the entire group (15.9% vs 9.3%, p = 0.03) and in HIV seropositive patients (52.0% vs 24.0%; p = 0.007). However, the sensitivity of GeneXpert MTB/RIF test compared to that in Ziehl-Neelsen staining wasn't maximum (95.2%). Finally, GeneXpert MTB/RIF test detected rifampicin resistance in 20.8%.

conclusionThis study confirms the superiority of GeneXpert MTB/RIF test compared to Ziehl-Neelsen staining in the detection of tuberculosis and in the prediction of multi-resistance. Its systematic use coupled with Ziehl-Neelsen staining would better control tuberculosis in sub-Saharan Africa.

Indexed as

AdultAntitubercular AgentsDemocratic Republic of the CongoDrug Resistance, Multiple, BacterialFemaleHIV SeropositivityHumansMaleMiddle AgedMolecular Diagnostic TechniquesMycobacterium tuberculosisRetrospective StudiesRifampinSensitivity and SpecificityStaining and LabelingTuberculosis, PulmonaryAntitubercular AgentsRifampinBukavuGeneXpert MTB / RIFscreeningtuberculosis

Identifiers

PMID29187929
PMCPMC5660310
OpenAlexW2745267360

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.