Detection of Treatment Success after Photodynamic Therapy Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging.

Tom J L Schreurs, Igor Jacobs, Klaas Nicolay, Jeanine J Prompers, Gustav J Strijkers

Open access · goldAbstract read

In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

2.1field-weighted citation impact, top 13% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging.Theranostics · 2020
Article
Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI.Theranostics · 2020
Article
Noninvasive assessment and therapeutic monitoring of drug-resistant colorectal cancer by MR molecular imaging of extradomain-B fibronectin.Theranostics · 2020
Article
Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice.Magnetic resonance in medicine · 2018
Article
Aptamer-functionalized nanoscale metal-organic frameworks for targeted photodynamic therapy.Theranostics · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Tom J L SchreursEindhoven University of Technology, Biomedical Engineering Department, Biomedical NMR, Eindhoven, The Netherlands.

Igor JacobsEindhoven University of Technology, Biomedical Engineering Department, Biomedical NMR, Eindhoven, The Netherlands.

Klaas NicolayEindhoven University of Technology, Biomedical Engineering Department, Biomedical NMR, Eindhoven, The Netherlands.

Jeanine J PrompersEindhoven University of Technology, Biomedical Engineering Department, Biomedical NMR, Eindhoven, The Netherlands.

Gustav J StrijkersAcademic Medical Center, Biomedical Engineering and Physics, Amsterdam, The Netherlands.

Eindhoven University of Technology · NLAcademic Medical Center · NLPhilips (Netherlands) · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early evaluation of response to therapy is crucial for selecting the optimal therapeutic follow-up strategy for cancer patients. PDT is a photochemistry-based treatment modality that induces tumor tissue damage by cytotoxic oxygen radicals, generated by a pre-injected photosensitive drug upon light irradiation of tumor tissue. Vascular shutdown is an important mechanism of tumor destruction for most PDT protocols. In this study, we assessed the suitability of Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to evaluate treatment efficacy within a day after photodynamic therapy (PDT), using the tumor vascular response as a biomarker for treatment success.

Indexed as

PhotochemotherapyAnimalsCell Line, TumorMagnetic Resonance AngiographyMiceMice, Inbred BALB CNeoplasms, ExperimentalNeovascularization, PathologicDynamic contrast-enhanced magnetic resonance imagingmouse tumor modelphotodynamic therapytreatment response evaluationtumor perfusion

Identifiers

PMID29187893

DOI10.7150/thno.20418

PMCPMC5706089

OpenAlexW2766331780

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.