ReviewFrontiers in microbiology2017
Microbiome Datasets Are Compositional: And This Is Not Optional.
Review in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,550 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Defining the Vaginal Microbiome and the Vaginal pH of Menopausal Women With and Without Genitourinary Syndrome and With and Without Hormone Replacement Therapy
Milk for Diabetes Prevention
Who cites it
1,550 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Functional Equivalence and Conserved Sexual Dimorphism in the Gut Microbiome: A Cross-Species Meta-analysis.Journal of molecular evolution · 2026Pooled it
- Prenatal Maternal Stress and Infant Gut Microbiome in Human and Animal Studies: A Comprehensive Systematic Review.Developmental psychobiology · 2026Pooled it
- Assessing the Impact ofNutrients · 2026Trial
- Early Microbiological and Immunological Parameters in Sandblasted, Large-Grit Acid-Etched Implant Surfaces: A Split Mouth Randomized Clinical Trial.Clinical oral implants research · 2026Trial
- Towards standardized gut microbiota diagnostics: normobiosis beyond geographical borders.Gut microbes · 2026Article
- Longitudinal gut microbiome dynamics are associated with clinical outcome and toxicity during ibrutinib therapy.Gut microbes · 2026Article
- Why probiotics fail: gut niche tension as the missing variable?Gut microbes · 2026Review
- Correspondence for the article: "Association between gut microbiota and sarcopenia in older adults: a cross-sectional analysis from the second wave of the Birjand Longitudinal Aging Study (BLAS)".Aging clinical and experimental research · 2026Article
- Artificial intelligence in human microbiome research: from data integration to explainable translation.Archives of microbiology · 2026Review
- Lung microbiome features associated with ICU delirium in mechanically ventilated patients: a secondary cohort analysis.Brain, behavior, & immunity - health · 2026Article
- Simplifying Macroinvertebrate Biodiversity Assessment: A Standardised Metabarcoding Method for Invertebrate Samples With High Volumes of Debris.Molecular ecology resources · 2026Article
- Disturbance History Shapes Microbial Community Assembly and Predictability in a Continuous Culture System.Environmental microbiology · 2026Article
- Citizen Sailors Provide a Detailed Map of Open-Ocean Surface Biodiversity and Help Link eDNA Data to Satellite Observations.Molecular ecology · 2026Article
- The Adult Aedes aegypti Bacterial Microbiota is Robust to Infection with the Obligate Microsporidian Parasite Edhazardia aedis.Environmental microbiology · 2026Article
- Beyond the Rumen: Current Evidence and Knowledge Gaps in Microbial Diversity and Function Across the Bovine Gastrointestinal Tract.Current microbiology · 2026Review
- Chemical Game Theory: Linking Metabolite Diversity, Biosynthetic Architecture, and Realized Payoffs.Molecules (Basel, Switzerland) · 2026Article
- Article
- Metagenomic analysis of the midgut microbiome in Dermacentor abaensis ticks at different feeding states.Experimental & applied acarology · 2026Article
- Towards an Omics-Guided Framework for Microbial Biological Control of Fungal and Oomycete Diseases inInternational journal of molecular sciences · 2026Review
- Multi-approach integrating water quality variables, remote sensing, eDNA and histopathology for assessing the impact of microbial pollution on Nile Tilapia from Kitchener Drain, Northern Egypt.BMC microbiology · 2026Article
1,490 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Datasets collected by high-throughput sequencing (HTS) of 16S rRNA gene amplimers, metagenomes or metatranscriptomes are commonplace and being used to study human disease states, ecological differences between sites, and the built environment. There is increasing awareness that microbiome datasets generated by HTS are compositional because they have an arbitrary total imposed by the instrument. However, many investigators are either unaware of this or assume specific properties of the compositional data. The purpose of this review is to alert investigators to the dangers inherent in ignoring the compositional nature of the data, and point out that HTS datasets derived from microbiome studies can and should be treated as compositions at all stages of analysis. We briefly introduce compositional data, illustrate the pathologies that occur when compositional data are analyzed inappropriately, and finally give guidance and point to resources and examples for the analysis of microbiome datasets using compositional data analysis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.