ArticleNutrition and dietary supplements2017
The effect of micronutrient supplementation on active TB incidence early in HIV infection in Botswana.
Article in Nutrition and dietary supplements, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Recent progress in understanding ferroptosis mechanisms in infectious diseases.Frontiers in cellular and infection microbiology · 2026Review
- Impact of L-arginine and L-citrulline supplementation on macrophage responses toFrontiers in immunology · 2026Article
- Selenium nutritional status and thyroid dysfunction.Archives of endocrinology and metabolism · 2025Review
- MEAN DIFFERENCE OF ZINC AND SELENIUM LEVELS AND TUBERCULOSIS OUTCOMES IN CHILDREN RECEIVING TREATMENT IN INDONESIA.African journal of infectious diseases · 2025Article
- Nutraceuticals as Modulators of Immune Function: A Review of Potential Therapeutic Effects.Preventive nutrition and food science · 2023Review
- Review on the health-promoting effect of adequate selenium status.Frontiers in nutrition · 2023Review
- Impact of micro- and macronutrient status on the incidence of tuberculosis: An examination of an African cohort initiating antiretroviral therapy.PLOS global public health · 2023Article
- Undernutrition is feeding the tuberculosis pandemic: A perspective.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Review
- Role of Vitamin A Supplementation in Prevention and Control of Coronavirus Disease-19: A Narrative Review.International journal of preventive medicine · 2022Review
- A literature review on beneficial role of vitamins and trace elements: Evidence from published clinical studies.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021Review
- The Interplay Between Systemic Inflammation, Oxidative Stress, and Tissue Remodeling in Tuberculosis.Antioxidants & redox signaling · 2021Review
- Macrophage Selenoproteins Restrict Intracellular Replication ofFrontiers in immunology · 2021Article
- Emerging Role for Ferroptosis in Infectious Diseases.Advances in experimental medicine and biology · 2021Review
- Selenium intake, status, and health: a complex relationship.Hormones (Athens, Greece) · 2020Review
- Role of Selenoproteins in Bacterial Pathogenesis.Biological trace element research · 2019Review
- Population Structure and Implications on the Genetic Architecture of HIV-1 Phenotypes Within Southern Africa.Frontiers in genetics · 2019Review
- Role of Vitamin A in the Immune System.Journal of clinical medicine · 2018Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCoinfection with active tuberculosis (TB) is one of the leading causes of death in people living with HIV (PLWH) in Africa. This investigation explores the role of micronutrient supplementation in preventing active TB in PLWH.
methodsA randomized trial of nutritional supplementation was conducted among antiretroviral- naïve (without previous antiretroviral treatment [ART]) HIV-infected people in Botswana between 2004 and 2009. The study had a factorial design with four arms: the selenium (Se) alone arm, the multivitamins (MVT) alone arm that contained vitamin B complex and vitamins C and E, the combined Se+MVT group and the placebo group. Those participants with prior or current active TB were excluded, as were participants with advanced HIV disease (CD4 <250 cells/μL) or who had already qualified for ART. HIV-positive adults (N=878) were followed monthly for study pill dispensation, every 3 months for CD4 cell count and every 6 months for viral load during 24 months or until they were started on ART.
resultsThe participants' characteristics were not significantly different among the four groups at baseline. Supplementation with Se alone (hazard ratio =0.20, 95% confidence interval: 0.04, 0.95,
conclusionSe supplementation, alone and with MVT, decreased the incidence of TB disease in PLWH who were ART-naïve. Supplementation with these micronutrients should be considered in HIV infection, prior to ART, in areas where TB and malnutrition are endemic.
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