Evidence map›Paper›PMID 29187761›Full record

ArticleMikrochimica acta2017

Gold nanocage-based lateral flow immunoassay for immunoglobulin G.

Yunhui Yang, Mehmet Ozsoz, Guodong Liu

Abstract read
In one paragraph

Article in Mikrochimica acta, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yunhui YangCollege of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, People's Republic of China.
Mehmet OzsozDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58105, USA.
Guodong LiuDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58105, USA.

Funding

Targeting CLEC-2/podoplanin as a therapeutic strategy for pancreatic cancerP20GM109024 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Megan Orr · 2016 to 2026
$20.5M
NIGMS NIH HHS P20 GM109024
6 · The paper itself

Abstract

The authors describe a gold nanocage-based lateral flow strip biosensor (LFSB) for low-cost and sensitive detection of IgG. This protein was used as a model analyte to demonstrate the proof-of-concept. The method combines the unique optical properties of gold nanocages (GNCs) with highly efficient chromatographic separation. A sandwich-type of immunoreactions occurs on the GNC-based LFSB which has the attractive features of avoiding multiple incubation, separation, and washing steps. The captured GNCs on the purple test zone and control zone of the biosensor are producing characteristic purple bands, and this enables IgG even to be visually detected. Quantitatation was accomplished by reading the intensities of the bands with a portable strip reader. The LFSB fabrication and assay parameters were optimized. The biosensor displays a linear response in the 0.5 to 50 ng·mL

Indexed as

AnimalsBiosensing TechniquesGoatsGoldImmunoassayImmunoglobulin GLimit of DetectionMetal NanoparticlesRabbitsSensitivity and SpecificityGoldImmunoglobulin GCellulose fiberGold nanocagesImmunoassayImmunoglobulin GLateral flow stripNitrocellulose

Identifiers

PMID29187761
PMCPMC5703415

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.