ArticleTranslational psychiatry2017
Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders.Nature human behaviour · 2024Pooled it
- Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism.Blood advances · 2023Pooled it
- Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.Molecular psychiatry · 2022Pooled it
- Exploring the shared genetic architecture and causal relationship between childhood maltreatment and psychiatric disorders.Molecular psychiatry · 2026Article
- Phenome-wide screening of the putative causal determinants of bipolar affective disorder using genetic data.PloS one · 2026Article
- Shared Genetic Architecture and Neurobiological Pathways of Problematic Alcohol Use and Anxiety Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Genetic Association of Mood Swings with Lung Function and Respiratory Diseases.Journal of personalized medicine · 2025Article
- Article
- Neurodevelopment Genes Encoding Olduvai Domains Link Myalgic Encephalomyelitis to Neuropsychiatric Disorders.Diagnostics (Basel, Switzerland) · 2025Article
- Ultra-processed food, genetic predisposition, and the risk of kidney stone: a population-based prospective cohort study.European journal of nutrition · 2025Article
- New Evidence for the Role of the Blood-Brain Barrier and Inflammation in Stress-Associated Depression: A Gene-Environment Analysis Covering 19,296 Genes in 109,360 Humans.International journal of molecular sciences · 2024Article
- DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress.Neurobiology of stress · 2024Article
- Rare coding variant analysis for human diseases across biobanks and ancestries.Nature genetics · 2024Article
- The Causal Effects between Mood Swings and Gastrointestinal Diseases: A Mendelian Randomization Study.Alpha psychiatry · 2024Article
- HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization.Translational psychiatry · 2023Article
- Hippocampal RNA sequencing in mice selectively bred for high and low activity.Genes, brain, and behavior · 2023Article
- Exploring the Genetic Link Between Thyroid Dysfunction and Common Psychiatric Disorders: A Specific Hormonal or a General Autoimmune Comorbidity.Thyroid : official journal of the American Thyroid Association · 2023Article
- Genetics of psycho-emotional well-being: genome-wide association study and polygenic risk score analysis.Frontiers in psychiatry · 2023Article
- The shared genetic basis of mood instability and psychiatric disorders: A cross-trait genome-wide association analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Article
- Affective Instability, Depression, and Anxiety Symptoms in a Community Sample of Pregnant and Postpartum Women: A Cross-Sectional Study.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Mood instability is a core clinical feature of affective and psychotic disorders. In keeping with the Research Domain Criteria approach, it may be a useful construct for identifying biology that cuts across psychiatric categories. We aimed to investigate the biological validity of a simple measure of mood instability and evaluate its genetic relationship with several psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD), schizophrenia, attention deficit hyperactivity disorder (ADHD), anxiety disorder and post-traumatic stress disorder (PTSD). We conducted a genome-wide association study (GWAS) of mood instability in 53,525 cases and 60,443 controls from UK Biobank, identifying four independently associated loci (on chromosomes 8, 9, 14 and 18), and a common single-nucleotide polymorphism (SNP)-based heritability estimate of ~8%. We found a strong genetic correlation between mood instability and MDD (r
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