Evidence map›Paper›PMID 29187699›Full record

ArticleExperimental animals2018

Establishment of an Alzheimer's disease model with latent herpesvirus infection using PS2 and Tg2576 double transgenic mice.

Seiichi Tanaka, Hiroshi Nagashima

Open access · diamondAbstract read
In one paragraph

Article in Experimental animals, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. The Use of Antimicrobial and Antiviral Drugs in Alzheimer's Disease.International journal of molecular sciences · 2020
    Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Seiichi TanakaCenter for Experimental Animals, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka-shi, Fukuoka 814-0180, Japan.
Hiroshi NagashimaAnimal-care Co., Ltd., 5-18-14 Shinjuku, Shinjuku-ku, Tokyo 160-0022, Japan.
Fukuoka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A relationship between Alzheimer's disease and herpes simplex virus infection has been pointed out. We established a model of Alzheimer's disease with a latent herpesvirus infection using a mouse model of Alzheimer's disease (PS2Tg2576) and examined the changes in amyloid β (Aβ) in the brain. We crossbred female PS2 mice with male Tg2576 hemi mice and chose PS2Tg2576 mice. After priming 5-week-old male mice with anti-pseudorabies virus swine serum, we challenged the mouse with 100 LD

Indexed as

Alzheimer DiseaseDisease Models, AnimalMice, TransgenicPseudorabiesAmyloid beta-PeptidesAnimalsBrainDNA, ViralFemaleHerpesvirus 1, SuidMaleTrefoil Factor-1Virus ActivationAmyloid beta-PeptidesDNA, ViralTff1 protein, mouseTrefoil Factor-1Alzheimer’s diseaseherpesviruslatent infectionpseudorabies virus

Identifiers

PMID29187699
PMCPMC5955750
OpenAlexW2768276837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.