Evidence map›Paper›PMID 29187564›Full record

ArticleJournal of clinical microbiology2018

A Comparison of Aspergillus and Mucorales PCR Testing of Different Bronchoalveolar Lavage Fluid Fractions from Patients with Suspected Invasive Pulmonary Fungal Disease.

Jan Springer, P Lewis White, Johanna Kessel, Imke Wieters, Daniel Teschner, Daniel Korczynski, Tobias Liebregts, Oliver A Cornely, Stefan Schwartz, Thomas Elgeti and 9 more

Open access · bronzeAbstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Detection ofJournal of clinical microbiology · 2025
    Article
  4. Article
  5. Article
  6. Clinical Implementation ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Review
  9. Review
  10. Detection and identification ofFrontiers in cellular and infection microbiology · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Epidemiology and Diagnosis of Mucormycosis: An Update.Journal of fungi (Basel, Switzerland) · 2020
    Review
  16. Article
  17. Detection ofJournal of fungi (Basel, Switzerland) · 2019
    Article
  18. Article
  19. Molecular Strategies to Diagnose Mucormycosis.Journal of fungi (Basel, Switzerland) · 2019
    Review
  20. Genotyping ofFrontiers in cellular and infection microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 2 countries.

Jan SpringerMedizinische Klinik und Poliklinik II, University Hospital Würzburg, Würzburg, Germany.
P Lewis WhitePublic Health Wales Microbiology, Cardiff, United Kingdom.
Johanna KesselMedizinische Klinik II, University Hospital Frankfurt, Frankfurt, Germany.
Imke WietersMedizinische Klinik II, University Hospital Frankfurt, Frankfurt, Germany.
Daniel TeschnerDepartment of Hematology, Medical Oncology, and Pneumology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Daniel KorczynskiDepartment of Hematology, Medical Oncology, and Pneumology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Tobias LiebregtsDepartment of Bone Marrow Transplantation, University Hospital Essen, Essen, Germany.
Oliver A CornelyCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Department I of Internal Medicine, Clinical Trials Centre Cologne (ZKS Köln), German Centre for Infection Research (DZIF), University of Cologne, Cologne, Germany.
Stefan SchwartzMedizinische Klinik m. S. Hämatologie und Onkologie, Charité Berlin, Berlin, Germany.
Thomas ElgetiKlinik für Radiologie und Klinik für Nuklearmedizin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Lisa MeintkerErlangen University Hospital, University of Erlangen, Erlangen, Germany.
Stefan W KrauseErlangen University Hospital, University of Erlangen, Erlangen, Germany.
Raquel B PossoPublic Health Wales Microbiology, Cardiff, United Kingdom.
Werner J HeinzMedizinische Klinik und Poliklinik II, University Hospital Würzburg, Würzburg, Germany.
Sandra FuhrmannDepartment I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Jörg Janne VehreschildDepartment I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Hermann EinseleMedizinische Klinik und Poliklinik II, University Hospital Würzburg, Würzburg, Germany.
Volker RickertsRobert Koch Institut Berlin, Berlin, Germany.
Juergen LoefflerMedizinische Klinik und Poliklinik II, University Hospital Würzburg, Würzburg, Germany loeffler_j@ukw.de.ORCID 0000-0001-6619-1100
Universitätsklinikum Würzburg · DEGerman Center for Infection Research · DEGoethe University Frankfurt · DEJohannes Gutenberg University Mainz · DEPublic Health Wales · GBCharité - Universitätsmedizin Berlin · DEEssen University Hospital · DEKlinik und Poliklinik für Nuklearmedizin · DERobert Koch Institute · DEUniversity of Cologne · DE

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
NIAID NIH HHS UM1 AI104681
6 · The paper itself

Abstract

In patients with hematological malignancies, bronchoalveolar lavage fluid (BALF) specimens are commonly used for the diagnosis of mold infections. However, it is not clear whether the cell pellet (P) or the supernatant fraction (S) of the BALF specimen is optimal for molecular diagnostic testing. Thus, 99 BALF specimens were collected from 96 hematology patients with or without allogeneic hematopoietic stem cell transplant. The cell pellets and supernatants were processed alone and in combination (S/P) for testing by two fungus-specific real-time PCR assays compliant with international recommendations. The results achieved with S/P were revealed to be superior in comparison to those achieved with S and P alone, with the use of each single fraction showing a reduced sensitivity for the detection of

Indexed as

Real-Time Polymerase Chain ReactionAdultAgedAged, 80 and overAspergillusBronchoalveolar Lavage FluidDNA, FungalHumansInvasive Fungal InfectionsInvasive Pulmonary AspergillosisMiddle AgedMolecular Diagnostic TechniquesMucoralesSensitivity and SpecificityYoung AdultDNA, FungalAspergillusbronchoalveolar lavage fluidmoldMucoralesPCRpelletsupernatant

Identifiers

PMID29187564
PMCPMC5786722
OpenAlexW2791652231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.