Evidence map›Paper›PMID 29187543›Full record

ArticleJournal of virology2018

A Proteomics Survey of Junín Virus Interactions with Human Proteins Reveals Host Factors Required for Arenavirus Replication.

Christopher M Ziegler, Philip Eisenhauer, Jamie A Kelly, Loan N Dang, Vedran Beganovic, Emily A Bruce, Benjamin R King, David J Shirley, Marion E Weir, Bryan A Ballif and 1 more

Abstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. ATP5B Is an Essential Factor for Hepatitis B Virus Entry.International journal of molecular sciences · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
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  17. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christopher M ZieglerDepartment of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA.
Philip EisenhauerDepartment of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA.
Jamie A KellyDepartment of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA.
Loan N DangDepartment of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA.
Vedran BeganovicDepartment of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA.
Emily A BruceDepartment of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA.
Benjamin R KingDepartment of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0003-2919-3961
David J ShirleyDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA.
Marion E WeirDepartment of Biology, University of Vermont, Burlington, Vermont, USA.
Bryan A BallifDepartment of Biology, University of Vermont, Burlington, Vermont, USA.
Jason BottenDepartment of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA jbotten@uvm.edu.

Funding

Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHRISTOPHER S FRANCKLYN · 2012 to 2026
$58.4M
VERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2006 to 2011
$14.5M
Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8M
Multidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1M
Vermont Immunology/Infectious Diseases Training GrantT32AI055402 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GARY E WARD · 2005 to 2026
$2.7M
Identification of Novel Arenavirus Protein-Host Cellular Protein InteractionsR21AI088059 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOTTEN, JASON W. · 2010 to 2011
$416k
NCRR NIH HHS P20 RR021905NHLBI NIH HHS T32 HL076122NIAID NIH HHS R21 AI088059NIAID NIH HHS T32 AI055402NIGMS NIH HHS P20 GM103449NIGMS NIH HHS P30 GM118228
6 · The paper itself

Abstract

Arenaviruses are negative-strand, enveloped RNA viruses that cause significant human disease. In particular, Junín mammarenavirus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. At present, little is known about the cellular proteins that the arenavirus matrix protein (Z) hijacks to accomplish its various functions, including driving the process of virus release. Furthermore, there is little knowledge regarding host proteins incorporated into arenavirus particles and their importance for virion function. To address these deficiencies, we used mass spectrometry to identify human proteins that (i) interact with the JUNV matrix protein inside cells or within virus-like particles (VLPs) and/or (ii) are incorporated into

Indexed as

Host-Pathogen InteractionsVirus ReplicationHEK293 CellsHemorrhagic Fever, AmericanHumansJunin virusProteomeProteomicsViral Matrix ProteinsVirus ReleaseProteomeViral Matrix ProteinsarenavirusbuddingESCRTinteractomeJunín viruslymphocytic choriomeningitis virusmammarenavirusmatrix proteinmatrix protein Zprotein-protein interactionsproteomicsRab5virus particleVLPZ

Identifiers

PMID29187543
PMCPMC5790945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.