Evidence map›Paper›PMID 29187538›Full record

ArticleJournal of virology2018

The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection.

Shaohui Wang, Kevin R Mott, Marianne Cilluffo, Casey L Kilpatrick, Shoko Murakami, Alexander V Ljubimov, Konstantin G Kousoulas, Sita Awasthi, Bernhard Luscher, Homayon Ghiasi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Shaohui WangCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, California, USA.
Kevin R MottCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, California, USA.
Marianne CilluffoBrain Research Institute, UCLA, Los Angeles, California, USA.
Casey L KilpatrickDepartment of Biology, Biochemistry and Molecular Biology, and Psychiatry, Pennsylvania State University, University Park, Pennsylvania, USA.
Shoko MurakamiDepartment of Biology, Biochemistry and Molecular Biology, and Psychiatry, Pennsylvania State University, University Park, Pennsylvania, USA.
Alexander V LjubimovEye Program, Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, and David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Konstantin G KousoulasDivision of Biotechnology and Molecular Medicine, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.
Sita AwasthiInfectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Bernhard LuscherDepartment of Biology, Biochemistry and Molecular Biology, and Psychiatry, Pennsylvania State University, University Park, Pennsylvania, USA.
Homayon GhiasiCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, California, USA ghiasih@cshs.org.
Pennsylvania State University · USCedars-Sinai Medical Center · USLouisiana State University · USUniversity of Pennsylvania · US

Funding

The Role of gK in HSV-1 Induced Corneal ScarringR01EY013615 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2002 to 2026
$7.8M
GABAergic Control of Depression Related Brain StatesR01MH099851 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI LUSCHER, BERNHARD · 2013 to 2019
$3.2M
Mapping the Neural Substrate of AnxietyR01MH060989 · NIMH · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI LUSCHER, BERNHARD · 2001 to 2009
$2.2M
Clustering and Synaptic Targeting of GABA-A ReceptorsR01MH062391 · NIMH · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI LUSCHER, BERNHARD · 2002 to 2006
$1.5M
NEI NIH HHS R01 EY013615NIMH NIH HHS R01 MH060989NIMH NIH HHS R01 MH062391NIMH NIH HHS R01 MH099851
6 · The paper itself

Abstract

UL20, an essential herpes simplex virus 1 (HSV-1) protein, is involved in cytoplasmic envelopment of virions and virus egress. We reported recently that UL20 can bind to a host protein encoded by the zinc finger DHHC-type containing 3 (

Indexed as

Virus LatencyVirus ReplicationAnimalsCell LineCorneaCytoplasmFemaleHerpes SimplexHerpesvirus 1, HumanLipoylationMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ElectronGODZ protein, mouseMembrane ProteinsUL20 protein, Herpes simplex virus type 1Viral ProteinsEMGODZHSV-1knockoutlatencylatency reactivationprimary infectionTGzinc finger protein

Identifiers

PMID29187538
PMCPMC5790959
OpenAlexW2768419517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.