Evidence map›Paper›PMID 29187535›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy.

Heaseung Sophia Chung, Grace E Kim, Ronald J Holewinski, Vidya Venkatraman, Guangshuo Zhu, Djahida Bedja, David A Kass, Jennifer E Van Eyk

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Proteomics of the heart.Physiological reviews · 2024
    Review
  4. Article
  5. Molecular medicine reports · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Bioinformatic Analysis of the Subproteomic Profile of Cardiomyopathic Tissue.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Heaseung Sophia ChungAdvanced Clinical BioSystems Research Institute, Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048.ORCID 0000-0003-1165-8388
Grace E KimDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Ronald J HolewinskiAdvanced Clinical BioSystems Research Institute, Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048.
Vidya VenkatramanAdvanced Clinical BioSystems Research Institute, Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048.
Guangshuo ZhuDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Djahida BedjaDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
David A KassDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; dkass1@jhmi.edu jennifer.vaneyk@cshs.org.
Jennifer E Van EykAdvanced Clinical BioSystems Research Institute, Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048; dkass1@jhmi.edu jennifer.vaneyk@cshs.org.
Cedars-Sinai Medical Center · USJohns Hopkins University · US

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
Protein Chemistry and ProteomicsP01HL112730 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI GOTTLIEB, ROBERTA A. · 2013 to 2017
$12.0M
Leveraging Protein Kinase G-1 Nanodomain Control and Molecular Targeting to Enhance its Therapeutic Use Against Myocardial DiseaseR35HL135827 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2017 to 2023
$6.3M
PKG Redox Modulation of Cardiac Function and DiseaseR01HL119012 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2013 to 2016
$1.6M
TRPC6 Hyperactivity and Cardiac DystrophinopathyR01HL131358 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2016 to 2016
$408k
CALPONIN AND DIFFERENTIATED VASCULAR SMOOTH MUSCLEF32HL010026 · NHLBI · UNIVERSITY OF NEVADA RENO · PI LEINWEBER, BARBARA D · 1998 to 2000
$38k
NHLBI NIH HHS F32 HL010026NHLBI NIH HHS P01 HL112730NHLBI NIH HHS R01 HL119012NHLBI NIH HHS R01 HL131358NHLBI NIH HHS R35 HL135827NHLBI NIH HHS T32 HL007227
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked disorder with dystrophin loss that results in skeletal and cardiac muscle weakening and early death. Loss of the dystrophin-sarcoglycan complex delocalizes nitric oxide synthase (NOS) to alter its signaling, and augments mechanosensitive intracellular Ca

Indexed as

AnimalsCalcium SignalingCysteineDisease Models, AnimalEpinephrineGene DeletionMaleMiceMice, Inbred C57BLMuscular Dystrophy, DuchenneMyocardiumNitrosationS-NitrosothiolsSympathomimeticsTRPC6 Cation ChannelTRPC Cation ChannelsCysteineEpinephrineS-NitrosothiolsSympathomimeticsTRPC6 Cation ChannelTrpc6 protein, mouseTRPC Cation ChannelsDuchenne muscular dystrophymass spectrometrynitric oxide synthase signalingprotein S-nitrosylationTrpc6

Identifiers

PMID29187535
PMCPMC5740634
OpenAlexW2772891875

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.