ArticleGenetics2018
Relaxed Selection During a Recent Human Expansion.
Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Inference of population demographic history captures differing evolutionary signals based on the number of individuals in the dataset.bioRxiv : the preprint server for biology · 2026Article
- Rare diseases load through the study of a regional population.PLoS genetics · 2025Article
- Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution.Evolutionary anthropology · 2025Review
- Frequency enrichment of coding variants in a French-Canadian founder population and its implication for inflammatory bowel diseases.medRxiv : the preprint server for health sciences · 2025Article
- Whole-genome relaxed selection and molecular constraints in Triplophysa under adapted Qinghai-Tibetan Plateau.BMC genomics · 2025Article
- Local Adaptation Is Highest in Populations With Stable Long-Term Growth.Ecology letters · 2025Article
- Chromosome-scale Reference Genome and RAD-based Genetic Map of Yellow Starthistle (Centaurea solstitialis) Reveal Putative Structural Variation and QTL Associated With Invader Traits.Genome biology and evolution · 2024Article
- Mitochondrial DNA Genomes Reveal Relaxed Purifying Selection During Human Population Expansion after the Last Glacial Maximum.Molecular biology and evolution · 2024Article
- Genome-wide relaxation of selection and the evolution of the island syndrome in Orkney voles.Genome research · 2024Article
- Genetic load and viability of a future restored northern white rhino population.Evolutionary applications · 2024Article
- Genomic signatures of bottleneck and founder effects in dingoes.Ecology and evolution · 2023Article
- Allele surfing causes maladaptation in a Pacific salmon of conservation concern.PLoS genetics · 2023Article
- Purging due to self-fertilization does not prevent accumulation of expansion load.PLoS genetics · 2023Article
- Deleterious Variation in Natural Populations and Implications for Conservation Genetics.Annual review of animal biosciences · 2023Review
- Molecular Genetic Characteristics ofGenes · 2023Article
- Recombination affects allele-specific expression of deleterious variants in human populations.Science advances · 2022Article
- Environment dependence of the expression of mutational load and species' range limits.Journal of evolutionary biology · 2022Article
- Article
- Benchmarking the performance of Pool-seq SNP callers using simulated and real sequencing data.Molecular ecology resources · 2021Article
- How Much DoesGenetics · 2020Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Humans have colonized the planet through a series of range expansions, which deeply impacted genetic diversity in newly settled areas and potentially increased the frequency of deleterious mutations on expanding wave fronts. To test this prediction, we studied the genomic diversity of French Canadians who colonized Quebec in the 17th century. We used historical information and records from ∼4000 ascending genealogies to select individuals whose ancestors lived mostly on the colonizing wave front and individuals whose ancestors remained in the core of the settlement. Comparison of exomic diversity reveals that: (i) both new and low-frequency variants are significantly more deleterious in front than in core individuals, (ii) equally deleterious mutations are at higher frequencies in front individuals, and (iii) front individuals are two times more likely to be homozygous for rare very deleterious mutations present in Europeans. These differences have emerged in the past six to nine generations and cannot be explained by differential inbreeding, but are consistent with relaxed selection mainly due to higher rates of genetic drift on the wave front. Demographic inference and modeling of the evolution of rare variants suggest lower effective size on the front, and lead to an estimation of selection coefficients that increase with conservation scores. Even though range expansions have had a relatively limited impact on the overall fitness of French Canadians, they could explain the higher prevalence of recessive genetic diseases in recently settled regions of Quebec.
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