Evidence map›Paper›PMID 29187506›Full record

ArticleGenetics2018

Cooperative Control of Ecdysone Biosynthesis in

Outa Uryu, Qiuxiang Ou, Tatsuya Komura-Kawa, Takumi Kamiyama, Masatoshi Iga, Monika Syrzycka, Keiko Hirota, Hiroshi Kataoka, Barry M Honda, Kirst King-Jones and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. AZoological research · 2026
    Article
  3. Article
  4. Single-cell transcriptomics of theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  8. Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Outa UryuFaculty of Life and Environmental Sciences, University of Tsukuba, 305-8572, Ibaraki, Japan.
Qiuxiang OuDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.ORCID 0000-0002-2961-2057
Tatsuya Komura-KawaGraduate School of Life and Environmental Sciences, University of Tsukuba, 305-8572, Ibaraki, Japan.ORCID 0000-0002-6583-7157
Takumi KamiyamaGraduate School of Life and Environmental Sciences, University of Tsukuba, 305-8572, Ibaraki, Japan.
Masatoshi IgaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.
Monika SyrzyckaDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Keiko HirotaFaculty of Life and Environmental Sciences, University of Tsukuba, 305-8572, Ibaraki, Japan.
Hiroshi KataokaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.
Barry M HondaDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Kirst King-JonesDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada kirst.king-jones@ualberta.ca ryusuke-niwa@umin.ac.jp.ORCID 0000-0002-9089-8015
Ryusuke NiwaFaculty of Life and Environmental Sciences, University of Tsukuba, 305-8572, Ibaraki, Japan kirst.king-jones@ualberta.ca ryusuke-niwa@umin.ac.jp.ORCID 0000-0002-1716-455X
University of Tsukuba · JPSimon Fraser University · CAJapan Science and Technology Agency · JPThe University of Tokyo · JPUniversity of Alberta · CA

Funding

CIHR MOP 93761
6 · The paper itself

Abstract

Ecdysteroids are steroid hormones that control many aspects of development and physiology. During larval development, ecdysone is synthesized in an endocrine organ called the prothoracic gland through a series of ecdysteroidogenic enzymes encoded by the Halloween genes. The expression of the Halloween genes is highly restricted and dynamic, indicating that their spatiotemporal regulation is mediated by their tight transcriptional control. In this study, we report that three zinc finger-associated domain (ZAD)-C

Indexed as

AllelesAnimalsDrosophilaEcdysoneGene Expression RegulationLarvaMutationPhenotypePromoter Regions, GeneticResponse ElementsTranscription FactorsZinc FingersEcdysoneTranscription FactorsDrosophilaecdysoneheterochromatinsteroid hormone biosynthesistranscriptionzinc finger

Identifiers

PMID29187506
PMCPMC5788525
OpenAlexW2770879807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.