Evidence map›Paper›PMID 29187504›Full record

ArticleGenetics2018

Tissue-Specific Gene Inactivation in

Bridget D DeLay, Mark E Corkins, Hannah L Hanania, Matthew Salanga, Jian Min Deng, Norihiro Sudou, Masanori Taira, Marko E Horb, Rachel K Miller

Abstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Article
  3. Comparative analysis ofbioRxiv : the preprint server for biology · 2025
    Article
  4. TheFrontiers in medicine · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Article
  18. Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bridget D DeLayDepartment of Pediatrics, Pediatric Research Center, University of Texas Health Science Center McGovern Medical School, Houston, Texas 77030.
Mark E CorkinsDepartment of Pediatrics, Pediatric Research Center, University of Texas Health Science Center McGovern Medical School, Houston, Texas 77030.ORCID 0000-0001-8261-6025
Hannah L HananiaDepartment of Pediatrics, Pediatric Research Center, University of Texas Health Science Center McGovern Medical School, Houston, Texas 77030.
Matthew SalangaNational Xenopus Resource and Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
Jian Min DengDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Norihiro SudouDepartment of Anatomy, School of Medicine, Tokyo Women's Medical University, 162-8666, Japan.
Masanori TairaDepartment of Biological Sciences, Graduate School of Science, University of Tokyo, 113-8654, Japan.
Marko E HorbNational Xenopus Resource and Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
Rachel K MillerDepartment of Pediatrics, Pediatric Research Center, University of Texas Health Science Center McGovern Medical School, Houston, Texas 77030 Rachel.K.Miller@uth.tmc.edu.

Funding

Resource CoreP40OD010997 · OD · MARINE BIOLOGICAL LABORATORY · PI Marko E Horb · 2012 to 2026
$13.1M
Xenopus models of human disease by targeted genome editingR01HD084409 · NICHD · MARINE BIOLOGICAL LABORATORY · PI HORB, MARKO E · 2015 to 2019
$2.9M
The Role of Planar Cell Polarity Signals in Shaping Kidney TubulesK01DK092320 · NIDDK · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILLER, RACHEL KATHERINE · 2012 to 2016
$584k
NICHD NIH HHS R01 HD084409NIDDK NIH HHS K01 DK092320NIH HHS P40 OD010997
6 · The paper itself

Abstract

Studying genes involved in organogenesis is often difficult because many of these genes are also essential for early development. The allotetraploid frog,

Indexed as

Gene SilencingAnimalsCRISPR-Cas SystemsGene EditingGene Knockout TechniquesGene TargetingKidneyLIM-Homeodomain ProteinsOrgan SpecificityPhenotypeRNA, Guide, CRISPR-Cas SystemsTranscription FactorsXenopus laevisXenopus ProteinsLhx1 protein, XenopusLIM-Homeodomain ProteinsRNA, Guide, CRISPR-Cas SystemsTranscription FactorsXenopus ProteinsCRISPRkidneylhx1targeted injectionXenopus laevis

Identifiers

PMID29187504
PMCPMC5788530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.