Evidence map›Paper›PMID 29187393›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib.

Ira L Kraft, Srivandana Akshintala, Yuelin Zhu, Haiyan Lei, Claudia Derse-Anthony, Eva Dombi, Seth M Steinberg, Maya Lodish, Steven G Waguespack, Oxana Kapustina and 7 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00514046 (Phase I/II Trial of Vandetanib), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00514046 phase1 / phase2completednot on this map

Phase I/II Trial of Vandetanib (ZD6474, ZACTIMA) in Children and Adolescents With Hereditary Medullary Thyroid Carcinoma

TypeinterventionalSponsorNational Cancer Institute (NCI)Ran2007 to 2020Enrolled17ConditionsMedullary Thyroid Carcinoma, Multiple Endocrine Neoplasia Type 2A, Multiple Endocrine Neoplasia Type 2BArmsVandetanib
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Pulmonary Function in Patients With Multiple Endocrine Neoplasia 2B.The Journal of clinical endocrinology and metabolism · 2020
    Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Ira L Kraft *Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Srivandana Akshintala *Department of Pediatrics, New York University Langone Medical Center, New York, New York.
Yuelin ZhuGenetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Haiyan LeiPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Claudia Derse-AnthonyClinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, Maryland.
Eva DombiPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Seth M SteinbergBiostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Maya LodishDevelopmental Endocrine Oncology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, Maryland.
Steven G WaguespackDepartment of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas.
Oxana KapustinaClinical Research, Harris IT Services, Sterling, Virginia.
Elizabeth FoxDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Frank M BalisDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Maria J MerinoTranslational Surgical Pathology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Paul S MeltzerGenetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
John W Glod *Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. John.Glod@nih.gov.
Jack F Shern *Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Brigitte C Widemann *Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
National Cancer Institute · USChildren's Hospital of Philadelphia · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USLeidos (United States) · USNYU Langone Health · USSterling Research Group · USThe University of Texas MD Anderson Cancer Center · US

Funding

Pediatric Oncology Branch Clinical Care and EducationZIEBC011516 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GLOD, JOHN · 2013 to 2025
$69.1M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z99 CA999999NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentCarcinoma, MedullaryChildDisease-Free SurvivalDisease ProgressionFemaleGerm-Line MutationHumansMaleMultiple Endocrine Neoplasia Type 2aOutcome Assessment, Health CarePiperidinesProtein Kinase InhibitorsQuinazolinesThyroid NeoplasmsPiperidinesProtein Kinase InhibitorsQuinazolinesvandetanib

Identifiers

PMID29187393
PMCPMC5815946
OpenAlexW2770034225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.