Evidence map›Paper›PMID 29187368›Full record

ArticleAmerican journal of physiology. Renal physiology2018

N-linked glycans are required on epithelial Na

Ossama B Kashlan, Carol L Kinlough, Michael M Myerburg, Shujie Shi, Jingxin Chen, Brandon M Blobner, Teresa M Buck, Jeffrey L Brodsky, Rebecca P Hughey, Thomas R Kleyman

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. The scaffold protein IQGAP1 regulates the epithelial NaThe Journal of biological chemistry · 2025
    Article
  2. Article
  3. Epithelial NaComprehensive Physiology · 2024
    Review
  4. Article
  5. Article
  6. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Paraoxonase 2 is an ER chaperone that regulates the epithelial NaAmerican journal of physiology. Cell physiology · 2022
    Article
  9. Enhanced Shear Force Responsiveness of Epithelial NaInternational journal of molecular sciences · 2021
    Article
  10. Article
  11. Article
  12. Shear force sensing of epithelial NaProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. The epithelial NaPflugers Archiv : European journal of physiology · 2019
    Article
  14. Analyses of epithelial NaThe Journal of biological chemistry · 2019
    Article
  15. Review
  16. Thumb domains of the three epithelial NaThe Journal of biological chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ossama B KashlanRenal Electrolyte Division, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Carol L KinloughRenal Electrolyte Division, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Michael M MyerburgDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Shujie ShiRenal Electrolyte Division, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Jingxin ChenRenal Electrolyte Division, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Brandon M BlobnerRenal Electrolyte Division, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Teresa M BuckDepartment of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania.
Jeffrey L BrodskyDepartment of Biological Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania.
Rebecca P HugheyRenal Electrolyte Division, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Thomas R KleymanRenal Electrolyte Division, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2008 to 2022
$13.4M
Biomechanical Regulation of Renal Ion TransportersR37DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2006 to 2015
$3.2M
ER Associated Degradation of Membrane Proteins in YeastR01GM075061 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L. · 2006 to 2019
$3.2M
Th2 inflammation promotes airway surface liquid dehydrationR01HL112863 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MYERBURG, MICHAEL M · 2012 to 2016
$1.9M
Allosteric ENaC RegulationR01DK098204 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KASHLAN, OSSAMA B · 2014 to 2018
$1.7M
SODIUM CHANNELS IN THE MAMMALIAN URINARY BLADDERR01DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R. · 1996 to 2005
$1.5M
Regulation of ENaC/degenerin channels by mechanical forcesK01DK103834 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2014 to 2018
$688k
Characterization of the ER associated Biogenesis and Degradation of ENaCK01DK090195 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUCK, TERESA M · 2011 to 2015
$497k
Investigating the role of GRP170 in ENaC biogenesisR03DK109024 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUCK, TERESA M · 2016 to 2017
$154k
NHLBI NIH HHS R01 HL112863NIDDK NIH HHS K01 DK090195NIDDK NIH HHS K01 DK103834NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK051391NIDDK NIH HHS R01 DK098204NIDDK NIH HHS R03 DK109024NIDDK NIH HHS R37 DK051391NIGMS NIH HHS R01 GM075061
6 · The paper itself

Abstract

Epithelial Na

Indexed as

Protein Processing, Post-TranslationalAnimalsEpithelial Sodium ChannelsGlycosylationMechanotransduction, CellularMembrane PotentialsMutationProtein ConformationProtein FoldingProtein TransportRats, Inbred F344SodiumStructure-Activity RelationshipTrypsinXenopus laevisEpithelial Sodium ChannelsScnn1a protein, mouseScnn1b protein, mouseScnn1g protein, mouseSodiumTrypsinepithelial sodium channelmaturationmechanosensationN-linked glycan

Identifiers

PMID29187368
PMCPMC5899221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.