Evidence map›Paper›PMID 29186823›Full record

ArticleAntioxidants (Basel, Switzerland)2017

The Subcellular Distribution of Alpha-Tocopherol in the Adult Primate Brain and Its Relationship with Membrane Arachidonic Acid and Its Oxidation Products.

Emily S. Mohn, Matthew J. Kuchan, John W. Erdman, Martha Neuringer, Nirupa R. Matthan, Chung-Yen Oliver Chen, Elizabeth J. Johnson

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Neuroprotective Effect of Antioxidants in the Brain.International journal of molecular sciences · 2020
    Review
  6. Vitamin E.Antioxidants (Basel, Switzerland) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Emily S. MohnJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA; Emily.Mohn@tufts.edu
Matthew J. KuchanDiscovery Research, Abbott Nutrition, Columbus, OH 43229, USA; Matthew.Kuchan@abbott.com
John W. ErdmanDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA; jwerdman@illinois.edu
Martha NeuringerOregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA; neuringe@ohsu.edu
Nirupa R. MatthanJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA; Nirupa.Matthan@tufts.edu
Chung-Yen Oliver ChenJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA; Oliver.Chen@tufts.edu
Elizabeth J. JohnsonJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA; Elizabeth.Johnson@tufts.edu
Tufts University · USDiscovery Laboratories (United States) · USJean Mayer Human Nutrition Research Center on Aging · USOregon Health & Science University · USUniversity of Illinois Urbana-Champaign · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NIH HHS P51 OD011092
6 · The paper itself

Abstract

The relationship between α-tocopherol, a known antioxidant, and polyunsaturated fatty acid (PUFA) oxidation, has not been directly investigated in the primate brain. This study characterized the membrane distribution of α-tocopherol in brain regions and investigated the association between membrane α-tocopherol and PUFA content, as well as brain PUFA oxidation products. Nuclear, myelin, mitochondrial, and neuronal membranes were isolated using a density gradient from the prefrontal cortex (PFC), cerebellum (CER), striatum (ST), and hippocampus (HC) of adult rhesus monkeys (

Indexed as

arachidonic acidbrainisoprostanesmembranesrhesus monkeyα-tocopherol

Identifiers

PMID29186823
PMCPMC5745507
OpenAlexW2768688372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.