Evidence map›Paper›PMID 29186784›Full record

ArticleMolecules (Basel, Switzerland)2017

Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies.

Alejandra Vázquez-Raygoza, Lucia Cano-González, Israel Velázquez-Martínez, Pedro Josué Trejo-Soto, Rafael Castillo, Alicia Hernández-Campos, Francisco Hernández-Luis, Jesús Oria-Hernández, Adriana Castillo-Villanueva, Claudia Avitia-Domínguez and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Targeted protein degradation might present a novel therapeutic approach in the fight against African trypanosomiasis.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2023
    Article
  2. Article
  3. Article
  4. Article
  5. Benzimidazole Derivatives as New and Selective Inhibitors of Arginase fromInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alejandra Vázquez-RaygozaFaculty of Medicine and Nutrition, Juarez University of Durango State, Av. Universidad y Fanny Anitua S/N, Durango 34000, Mexico
Lucia Cano-GonzálezSchool of Chemistry, Pharmacy Department, National Autonomous University of Mexico, Mexico City 04510, Mexico
Israel Velázquez-MartínezSchool of Chemistry, Pharmacy Department, National Autonomous University of Mexico, Mexico City 04510, Mexico
Pedro Josué Trejo-SotoSchool of Chemistry, Pharmacy Department, National Autonomous University of Mexico, Mexico City 04510, Mexico
Rafael CastilloSchool of Chemistry, Pharmacy Department, National Autonomous University of Mexico, Mexico City 04510, Mexico
Alicia Hernández-CamposSchool of Chemistry, Pharmacy Department, National Autonomous University of Mexico, Mexico City 04510, Mexico
Francisco Hernández-LuisSchool of Chemistry, Pharmacy Department, National Autonomous University of Mexico, Mexico City 04510, Mexico
Jesús Oria-HernándezBiochemistry and Genetics Laboratory, National Institute of Pediatrics, Ministry of Health, Mexico City 04534, Mexico
Adriana Castillo-VillanuevaBiochemistry and Genetics Laboratory, National Institute of Pediatrics, Ministry of Health, Mexico City 04534, Mexico
Claudia Avitia-DomínguezFaculty of Medicine and Nutrition, Juarez University of Durango State, Av. Universidad y Fanny Anitua S/N, Durango 34000, Mexico
Erick Sierra-CamposFaculty of Chemical Sciences, Juarez University of Durango State, Av. Artículo 123 S/N Fracc. Filadelfia, Gomez Palacio, Durango 35010, Mexico
Mónica Valdez-SolanaFaculty of Chemical Sciences, Juarez University of Durango State, Av. Artículo 123 S/N Fracc. Filadelfia, Gomez Palacio, Durango 35010, Mexico
Alfredo Téllez-ValenciaFaculty of Medicine and Nutrition, Juarez University of Durango State, Av. Universidad y Fanny Anitua S/N, Durango 34000, Mexico

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human African Trypanosomiasis (HAT), a disease that provokes 2184 new cases a year in Sub-Saharan Africa, is caused by

Indexed as

Models, MolecularBenzimidazolesDrug DesignHumansKineticsProtein BindingProtein ConformationSpecies SpecificityThermodynamicsTriose-Phosphate IsomeraseTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosomiasis, AfricanBenzimidazolesTriose-Phosphate IsomeraseTrypanocidal Agentsenzymatic kineticshuman African trypanosomiasismolecular dynamics simulationtriosephosphate isomerase

Identifiers

PMID29186784
PMCPMC6149853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.