SynthesisJournal of radiation research2018
Meta-analysis of thirty-two case-control and two ecological radon studies of lung cancer.
Synthesis in Journal of radiation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Systematic review and meta-analysis of residential radon and lung cancer in never-smokers.European respiratory review : an official journal of the European Respiratory Society · 2021Pooled it
- Residential Radon and Histological Types of Lung Cancer: A Meta-Analysis of Case‒Control Studies.International journal of environmental research and public health · 2020Pooled it
- Meta-analysis of case-control studies on the relationship between lung cancer and indoor radon exposure.Radiation and environmental biophysics · 2019Pooled it
- Radium - from discovery to the present day - narrative review.Clinical and experimental medicine · 2026Review
- Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.Biomedicines · 2026Review
- Population Studies and Molecular Mechanisms of Human Radioadaptive Capabilities: Is It Time to Rethink Radiation Safety Standards?International journal of molecular sciences · 2024Review
- Indoor radon exposure: A systematic review of radon-induced health risks and evidence quality using GRADE approach.Heliyon · 2024Article
- The enduring legacy of Marie Curie: impacts of radium in 21st century radiological and medical sciences.International journal of radiation biology · 2022Review
- Designing an Indoor Radon Risk Exposure Indicator (IRREI): An Evaluation Tool for Risk Management and Communication in the IoT Age.International journal of environmental research and public health · 2021Article
- Indoor Radon Concentration and Risk Assessment in 27 Districts of a Public Healthcare Company in Naples, South Italy.Life (Basel, Switzerland) · 2021Article
- Indoor radon exposure and excess of lung cancer mortality: the case of Mexico-an ecological study.Environmental geochemistry and health · 2021Article
- Cancer Incidence Trends in the Oil Shale Industrial Region in Estonia.International journal of environmental research and public health · 2020Article
- Multiple Stressor Effects of Radon and Phthalates in Children: Background Information and Future Research.International journal of environmental research and public health · 2020Review
- A Critique of Recent Epidemiologic Studies of Cancer Mortality Among Nuclear Workers.Dose-response : a publication of International Hormesis SocietyArticle
- Modeling Cell Reactions to Ionizing Radiation: From a Lesion to a Cancer.Dose-response : a publication of International Hormesis SocietyArticle
- Analysis of Indoor Radon Data Using Bayesian, Random Binning, and Maximum Entropy Methods.Dose-response : a publication of International Hormesis SocietyArticle
- Epidemiologic Studies Cannot Reveal the True Shape of the Dose-Response Relationship for Radon-Induced Lung Cancer.Dose-response : a publication of International Hormesis SocietyArticle
- Health Impacts of Low-Dose Ionizing Radiation: Current Scientific Debates and Regulatory Issues.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A re-analysis has been carried out of thirty-two case-control and two ecological studies concerning the influence of radon, a radioactive gas, on the risk of lung cancer. Three mathematically simplest dose-response relationships (models) were tested: constant (zero health effect), linear, and parabolic (linear-quadratic). Health effect end-points reported in the analysed studies are odds ratios or relative risk ratios, related either to morbidity or mortality. In our preliminary analysis, we show that the results of dose-response fitting are qualitatively (within uncertainties, given as error bars) the same, whichever of these health effect end-points are applied. Therefore, we deemed it reasonable to aggregate all response data into the so-called Relative Health Factor and jointly analysed such mixed data, to obtain better statistical power. In the second part of our analysis, robust Bayesian and classical methods of analysis were applied to this combined dataset. In this part of our analysis, we selected different subranges of radon concentrations. In view of substantial differences between the methodology used by the authors of case-control and ecological studies, the mathematical relationships (models) were applied mainly to the thirty-two case-control studies. The degree to which the two ecological studies, analysed separately, affect the overall results when combined with the thirty-two case-control studies, has also been evaluated. In all, as a result of our meta-analysis of the combined cohort, we conclude that the analysed data concerning radon concentrations below ~1000 Bq/m3 (~20 mSv/year of effective dose to the whole body) do not support the thesis that radon may be a cause of any statistically significant increase in lung cancer incidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.