ArticleEuropean journal of public health2017
Maternal serum bisphenol A levels and risk of pre-eclampsia: a nested case-control study.
Article in European journal of public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prediction of pregnancy-related hypertensive disorders using metabolomics: a systematic review.BMJ open · 2022Pooled it
- Environmental contaminants and preeclampsia: a systematic literature review.Journal of toxicology and environmental health. Part B, Critical reviews · 2018Pooled it
- Placental angiogenic biomarkers in relation to prenatal bisphenol and phthalate exposure.Placenta · 2026Article
- The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system†.Biology of reproduction · 2024Review
- The Effect of Bisphenol and Its Cytotoxicity on Female Infertility and Pregnancy Outcomes: A Narrative Review.Journal of clinical medicine · 2024Review
- Association of Phenols, Parabens, and Their Mixture with Maternal Blood Pressure Measurements in the PROTECT Cohort.Environmental health perspectives · 2024Article
- Bisphenol A-What Do We Know? A Global or Local Approach at the Public Health Risk Level.International journal of molecular sciences · 2024Review
- Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019.Frontiers in public health · 2024Article
- Review
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Exposure to endocrine disrupting chemicals (EDCs) and cardiometabolic indices during pregnancy: The HOME Study.Environment international · 2021Article
- REPRODUCTIVE TOXICOLOGY: Pregnancy exposure to endocrine disrupting chemicals: implications for women's health.Reproduction (Cambridge, England) · 2021Review
- Endocrine-Disrupting Chemical Exposures in Pregnancy: a Sensitive Window for Later-Life Cardiometabolic Health in Women.Current epidemiology reports · 2021Article
- Heightened susceptibility: A review of how pregnancy and chemical exposures influence maternal health.Reproductive toxicology (Elmsford, N.Y.) · 2020Review
- Oestrogenic Endocrine Disruptors in the Placenta and the Fetus.International journal of molecular sciences · 2020Review
- Placental microRNAs: Responders to environmental chemicals and mediators of pathophysiology of the human placenta.Toxicology reports · 2020Review
- Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Environmental Toxicant Exposure and Hypertensive Disorders of Pregnancy: Recent Findings.Current hypertension reports · 2018Review
- hCG and Its Disruption by Environmental Contaminants during Human Pregnancy.International journal of molecular sciences · 2018Review
- Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations.Frontiers in physiology · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Background: Although recent studies have indicated the potential adverse effects of maternal bisphenol A (BPA) exposure on pregnancy such as increasing the risk of pre-eclampsia, epidemiological evidence is limited. We aimed to evaluate the relationship between maternal BPA exposure and the risk of pre-eclampsia. Methods: We conducted a nested case-control study among 173 women (74 cases of pre-eclampsia and 99 controls). BPA concentrations were measured using liquid chromatography-mass spectrometry in the maternal serum samples collected during 16-20 gestational weeks. Multivariate logistic models were used to examine the relationship between maternal serum BPA concentrations and the risk of pre-eclampsia. Results: BPA was detectable (>0.1 µg/l) in 78.6% of the maternal serum samples at three levels: low (<2.24 µg/l), medium (2.24-4.44 µg/l), and high (>4.44 µg/l). BPA concentrations were significantly higher in the serum samples collected from the pre-eclampsia cases than those from controls (median: 3.40 vs. 1.50 µg/l, P < 0.01). With adjustment for maternal age, primiparous and BMI, the odds of developing pre-eclampsia were significantly elevated in subjects with high serum BPA levels compared with those with low levels (adjusted OR = 16.46, 95%CI = 5.42-49.85) regardless of subcategories of pre-eclampsia including severity and onset time. Among the pre-eclampsia subjects, the maternal serum concentration of BPA was not different between the early- and late-onset subjects (median: 3.09 vs. 3.50 µg/l, P = 0.57), but surprisingly higher in mild pre-eclampsia subjects compared with severe pre-eclampsia subjects (median: 5.20 vs. 1.80 µg/l, P < 0.01). Conclusions: These results demonstrated that maternal exposure to high level of BPA could be associated with an increased risk of pre-eclampsia.
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