ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Metabolites Associated With Risk of Developing Mobility Disability in the Health, Aging and Body Composition Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- Plasma acylcarnitines and risk of lower-extremity functional impairment in older adults: a nested case-control study.Scientific reports · 2021Trial
- Metabolomic Signatures of Physical Function and Functional Trajectories in Older Adults: Insights from the ENRGISE Clinical Trial.Metabolites · 2025Article
- Metabolic Markers Demonstrate the Heterogeneity of Walking Ability in Non-Disabled Community-Dwelling Older Adults.Metabolites · 2025Article
- Metabolomic Pathways of Inflammation and Mitochondrial Dysfunction Are Related to Worsening Healthy Aging Index and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Shared plasma metabolomic profiles of cognitive and mobility decline predict future dementia.GeroScience · 2024Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Metabolites Associated with Memory and Gait: A Systematic Review.Metabolites · 2022Review
- Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men.BMC geriatrics · 2022Article
- Specific Metabolites Involved in Antioxidation and Mitochondrial Function Are Correlated With Frailty in Elderly Men.Frontiers in medicine · 2022Article
- Plasma Ceramides and Risk of Impaired Lower-Extremity Function in Older Adults: A Nested Case-Control Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Metabolites Associated with Walking Ability Among the Oldest Old from the CHS All Stars Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Article
- Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men.Metabolites · 2019Article
- Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma-Application to Clinical and Epidemiology Cohorts.Analytical chemistry · 2019Article
- Targeted Metabolomics Shows Low Plasma Lysophosphatidylcholine 18:2 Predicts Greater Decline of Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Metabolic profiling of adherence to diet, physical activity and body size recommendations for cancer prevention.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
10 authors at 9 institutions in 2 countries.
Funding
Abstract
Background: Metabolic pathways that give rise to functional decline and mobility disability in older adults are incompletely understood. Methods: To identify metabolic perturbations that may affect functional decline, nontargeted metabolomics was used to measure 350 metabolites in baseline plasma from 313 black men in the Health ABC Study (median age 74 years). Usual gait speed was measured over 20 m. Cross-sectional relationships between gait speed and metabolites were explored with partial correlations adjusted for age, study site, and smoking status. Risk of incident mobility disability (two consecutive reports of severe difficulty walking quarter mile or climb 10 stairs) over 13 years of follow-up was explored with Cox regression models among 307 men who were initially free of mobility disability. Significance was determined at p ≤ .01 and q (false discovery rate) ≤ 0.30. Results: Two metabolites were correlated with gait speed: salicylurate (r = -.19) and 2-hydroxyglutarate (r = -.18). Metabolites of amino acids and amino acid degradation (indoxy sulfate; hazard ratio [HR] = 1.48, 95% confidence interval [CI] = 1.09-2.03, symmetric dimethylarginine; HR = 3.58, 95% CI = 1.57-8.15, N-carbamoyl beta-alanine; HR = 1.91, 95% CI = 1.16-3.14, quinolinate; HR = 2.56, 95% CI = 1.65-3.96) and metabolites related to kidney function (aforementioned symmetric dimethylarginine and indoxy sulfate as well as creatinine; HR = 5.91, 95% CI = 2.06-16.9, inositol; HR = 2.70, 95% CI = 1.47-4.97) were among the 23 metabolites associated with incident mobility disability. Conclusions: This study highlights the potential role of amino acid derivatives and products and kidney function early in the development of mobility disability and suggests metabolic profiles could help identify individuals at risk of functional decline.
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