ArticleCerebral cortex (New York, N.Y. : 1991)2018
Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Exposure to PMEuropean journal of pediatrics · 2023Pooled it
- Neural Effects of Physical Activity and Movement Interventions in Individuals With Developmental Disabilities-A Systematic Review.Frontiers in psychiatry · 2022Pooled it
- Cerebellar Contributions to Cerebral Connectivity in Severe Mental Illness: A Developmental Cascade and Predictive-Modeling Framework with Autistic Disorder as the Focal Case.Brain sciences · 2026Review
- Alterations in Early Alpha-band Connectivity emerge in Infancy among children later diagnosed with Autism.medRxiv : the preprint server for health sciences · 2026Article
- Markerless gait analysis for children and adolescents with juvenile idiopathic arthritis using a machine learning pipeline.Pediatric rheumatology online journal · 2026Article
- A null findings study: graph theoretical analysis of the fetal functional connectome shows no relationships with future autistic traits.Neuroimage. Reports · 2026Article
- Commonality and Variability in Functional Networks in Children Under 5 Years Old.bioRxiv : the preprint server for biology · 2026Article
- Fetal functional connectivity prospectively associates with autistic traits in toddlerhood.NeuroImage. Clinical · 2026Article
- Effects of a 6-Month Exercise Intervention on Primitive Reflexes in Children with Developmental Language Disorder-A Case for Multisensory and Sensorimotor Integration.Children (Basel, Switzerland) · 2025Article
- Comparative Evaluation of Assumption Lean Community Detection Methods for Human Connectome Networks.bioRxiv : the preprint server for biology · 2025Article
- Task-based functional connectivity in infants after exposure to regular white noise during natural sleep measured by fNIRS.Scientific reports · 2025Article
- Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds.Journal of neurodevelopmental disorders · 2025Article
- Quantitative EEG features for the prediction of short-term neuromotor development outcome in premature neonates.Scientific reports · 2025Article
- Functional connectivity between the visual and salience networks and autistic social features at school-age.Journal of neurodevelopmental disorders · 2025Article
- Statistical properties of functional connectivity MRI enrichment analysis in school-age autism research.Developmental cognitive neuroscience · 2025Article
- Cluster analysis of motor coordination and health-related fitness in preschool children: population classification and variable contribution based on principal component analysis.Frontiers in public health · 2025Article
- Motor competence development of children in Singapore: a cross-sectional and longitudinal study.PeerJ · 2025Article
- A Subset of Cortical Areas Exhibit Adult-like Functional Network Patterns in Early Childhood.bioRxiv : the preprint server for biology · 2024Article
- Atypical Brain Connectivity During Pragmatic and Semantic Language Processing in Children with Autism.Brain sciences · 2024Article
- Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 11 institutions in 2 countries.
Funding
Abstract
Infant gross motor development is vital to adaptive function and predictive of both cognitive outcomes and neurodevelopmental disorders. However, little is known about neural systems underlying the emergence of walking and general gross motor abilities. Using resting state fcMRI, we identified functional brain networks associated with walking and gross motor scores in a mixed cross-sectional and longitudinal cohort of infants at high and low risk for autism spectrum disorder, who represent a dimensionally distributed range of motor function. At age 12 months, functional connectivity of motor and default mode networks was correlated with walking, whereas dorsal attention and posterior cingulo-opercular networks were implicated at age 24 months. Analyses of general gross motor function also revealed involvement of motor and default mode networks at 12 and 24 months, with dorsal attention, cingulo-opercular, frontoparietal, and subcortical networks additionally implicated at 24 months. These findings suggest that changes in network-level brain-behavior relationships underlie the emergence and consolidation of walking and gross motor abilities in the toddler period. This initial description of network substrates of early gross motor development may inform hypotheses regarding neural systems contributing to typical and atypical motor outcomes, as well as neurodevelopmental disorders associated with motor dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.