ArticleCerebral cortex (New York, N.Y. : 1991)2019
Longitudinal Functional Brain Mapping in Supernormals.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- What characterizes the exceptional cognition of superagers? A systematic review of multidomain biomarkers of successful cognitive aging.The Gerontologist · 2026Pooled it
- Understanding brain resilience in superagers: a systematic review.Neuroradiology · 2021Pooled it
- BrainAGE in superagers: cross-sectional and longitudinal analyses in older adults aged 80+ with youthful episodic memory.GeroScience · 2025Article
- Functional Connectome of Superagers Reveals Early Markers of Resilience and Vulnerability to Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Identification of key brain networks and functional connectivities of successful aging: A surface-based resting-state functional magnetic resonance study.World journal of psychiatry · 2025Article
- Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project.The lancet. Healthy longevity · 2023Article
- Enhanced putamen functional connectivity underlies altered risky decision-making in age-related cognitive decline.Scientific reports · 2023Article
- Phenotyping Superagers Using Resting-State fMRI.AJNR. American journal of neuroradiology · 2023Article
- Functional activation features of memory in successful agers across the adult lifespan.NeuroImage · 2022Article
- The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study.BMC geriatrics · 2022Article
- The Brain Metabolic Signature in Superagers Using In VivoAJNR. American journal of neuroradiology · 2021Article
- Regional Cortical Thickness Predicts Top Cognitive Performance in the Elderly.Frontiers in aging neuroscience · 2021Article
- Stronger Functional Connectivity in the Default Mode and Salience Networks Is Associated With Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Cognitively supernormal older adults maintain a unique structural connectome that is resistant to Alzheimer's pathology.NeuroImage. Clinical · 2020Article
- Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Neurocognitive SuperAging in Older Adults Living With HIV: Demographic, Neuromedical and Everyday Functioning Correlates.Journal of the International Neuropsychological Society : JINS · 2019Article
- The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies.Brain : a journal of neurology · 2019Article
- Amyloid and FDG PET of Successful Cognitive Aging: Global and Cingulate-Specific Differences.Journal of Alzheimer's disease : JAD · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Prevention of age-related cognitive decline is an increasingly important topic. Recently, increased attention is being directed at understanding biological models of successful cognitive aging. Here, we examined resting-state brain regional low-frequency oscillations using functional magnetic resonance imaging in 19 older adults with excellent cognitive abilities (Supernormals), 28 older adults with normative cognition, 57 older adults with amnestic mild cognitive impairment, and 26 with Alzheimer's disease. We identified a "Supernormal map", a set of regions whose oscillations were resistant to the aging-associated neurodegenerative process, including the right fusiform gyrus, right middle frontal gyrus, right anterior cingulate cortex, left middle temporal gyrus, left precentral gyrus, and left orbitofrontal cortex. The map was unique to the Supernormals, differentiated this group from cognitive average-ager comparisons, and predicted a 1-year change in global cognition (indexed by the Montreal Cognitive Assessment scores, adjusted R2 = 0.68). The map was also correlated to Alzheimer's pathophysiological features (beta-amyloid/pTau ratio, adjusted R2 = 0.66) in participants with and without cognitive impairment. These findings in phenotypically successful cognitive agers suggest a divergent pattern of brain regions that may either reflect inherent neural integrity that contributes to Supernormals' cognitive success, or alternatively indicate adaptive reorganization to the demands of aging.
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