Evidence map›Paper›PMID 29186302›Full record

ReviewBriefings in bioinformatics2019

Translational bioinformatics in mental health: open access data sources and computational biomarker discovery.

Jessica D Tenenbaum, Krithika Bhuvaneshwar, Jane P Gagliardi, Kate Fultz Hollis, Peilin Jia, Liang Ma, Radhakrishnan Nagarajan, Gopalkumar Rakesh, Vignesh Subbian, Shyam Visweswaran and 2 more

Abstract readReview
In one paragraph

Review in Briefings in bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Fostering precision psychiatry through bioinformatics.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jessica D TenenbaumDepartment of Biostatistics and Bioinformatics at the Duke University School of Medicine.
Krithika BhuvaneshwarInnovation Center for Biomedical Informatics (ICBI) at Georgetown University.
Jane P GagliardiDuke University School of Medicine.
Kate Fultz HollisDepartment of Biomedical Informatics and Clinical Epidemiology at Oregon Health and Science University.
Peilin JiaUniversity of Texas Health Science Center at Houston.
Liang MaBioinformatics and Systems Medicine Laboratory (BSML), Center for Precision Health, School of Biomedical Informatics, the University of Texas Health Science Center at Houston.
Radhakrishnan NagarajanCollege of Medicine, University of Kentucky.
Gopalkumar RakeshDuke University Medical Center.
Vignesh SubbianDepartment of Biomedical Engineering and the Department of Systems and Industrial Engineering at the University of Arizona.
Shyam VisweswaranUniversity of Pittsburgh.
Zhongming ZhaoUniversity of Texas Health Science Center at Houston.
Leon RozenblitPrometheus Research.

Funding

Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
Transforming dbGaP genetic and genomic data to FAIR-ready by artificial intelligence and machine learning algorithmsR01LM012806 · NLM · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongming Zhao · 2017 to 2026
$3.7M
Development and Evaluation of a Learning Electronic Medical Record SystemR01LM012095 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VISWESWARAN, SHYAM · 2015 to 2018
$1.8M
Improved Disease Stratification Using Electronic Health RecordsK01LM012529 · NLM · DUKE UNIVERSITY · PI TENENBAUM, JESSICA D · 2017 to 2018
$377k
NCATS NIH HHS UL1 TR001117NLM NIH HHS K01 LM012529NLM NIH HHS R01 LM012095NLM NIH HHS R01 LM012806
6 · The paper itself

Abstract

Mental illness is increasingly recognized as both a significant cost to society and a significant area of opportunity for biological breakthrough. As -omics and imaging technologies enable researchers to probe molecular and physiological underpinnings of multiple diseases, opportunities arise to explore the biological basis for behavioral health and disease. From individual investigators to large international consortia, researchers have generated rich data sets in the area of mental health, including genomic, transcriptomic, metabolomic, proteomic, clinical and imaging resources. General data repositories such as the Gene Expression Omnibus (GEO) and Database of Genotypes and Phenotypes (dbGaP) and mental health (MH)-specific initiatives, such as the Psychiatric Genomics Consortium, MH Research Network and PsychENCODE represent a wealth of information yet to be gleaned. At the same time, novel approaches to integrate and analyze data sets are enabling important discoveries in the area of mental and behavioral health. This review will discuss and catalog into an organizing framework the increasingly diverse set of MH data resources available, using schizophrenia as a focus area, and will describe novel and integrative approaches to molecular biomarker discovery that make use of mental health data.

Indexed as

Computational BiologyMental HealthTranslational Research, BiomedicalBiomarkersHumansBiomarkersbiomarker discoverymental healthopen accesstranslational bioinformatics

Identifiers

PMID29186302
PMCPMC6585382

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.