ArticlePloS one2017
Intensive Care Syndrome: Promoting Independence and Return to Employment (InS:PIRE). Early evaluation of a complex intervention.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness: A Systematic Review and Critical Appraisal.Critical care medicine · 2020Pooled it
- Pooled it
- Piloting an ICU follow-up clinic to improve health-related quality of life in ICU survivors after a prolonged intensive care stay (PINA): feasibility of a pragmatic randomised controlled trial.BMC anesthesiology · 2023Trial
- Impaired Pre-Critical Illness Quality of Life in Elderly ICU Patients.Acta anaesthesiologica Scandinavica · 2026Observational
- PICS-SES postintensive care syndrome and socioeconomic status.Journal of intensive care · 2026Article
- Nursing Interventions for Post-Intensive Care Syndrome in Follow-Up Clinics: A Scoping Review.Nursing reports (Pavia, Italy) · 2026Review
- Post-Intensive Care Syndrome: From Diagnosis To Treatment.Deutsches Arzteblatt international · 2026Review
- Review
- Interventions for adult survivors discharged from the intensive care unit: a scoping review.BMJ open · 2025Article
- More self-efficacy is associated with longitudinally higher health-related quality of life in mechanically ventilated COVID-19 ICU survivors: The prospective MaastrICCht cohort.Nursing in critical care · 2025Article
- Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge (iRehab): a protocol for a randomised controlled assessor-blind clinical and cost-effectiveness trial.NIHR open research · 2025Article
- The Financial Impact of Post Intensive Care Syndrome.Critical care clinics · 2025Review
- Article
- Intensive care unit follow-up clinic activities: a scoping review.Journal of anesthesia · 2024Article
- Factors Associated With New Analgesic Requirements Following Critical Illness.Journal of intensive care medicine · 2024Observational
- Characterizing Cardiac Function in ICU Survivors of Sepsis: A Pilot Study Protocol.CHEST critical care · 2024Article
- Critical Care Education and the ICU Care Continuum.American journal of respiratory and critical care medicine · 2024Article
- Barriers to and Facilitators of Family Caregiving of Patients With COVID-19 Early in the Pandemic.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2023Article
- Best Practices in Oral Care.Critical care nurse · 2023Article
- Evaluation of a health and social care programme to improve outcomes following critical illness: a multicentre study.Thorax · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany patients suffer significant physical, social and psychological problems in the months and years following critical care discharge. At present, there is minimal evidence of any effective interventions to support this patient group following hospital discharge. The aim of this project was to understand the impact of a complex intervention for ICU survivors.
methodsQuality improvement project conducted between September 2014 and June 2016, enrolling 49 selected patients from one ICU in Scotland. To evaluate the impact of this programme outcomes were compared to an existing cohort of patients from the same ICU from 2008-2009. Patients attended a five week peer supported rehabilitation programme. This multidisciplinary programme included pharmacy, physiotherapy, nursing, medical, and psychology input. The primary outcome in this evaluation was the EQ-5D, a validated measure of health-related quality of life. The minimally clinically important difference (MCID) in the EQ-5D is 0.08. We also measured change in self-efficacy over the programme duration. Based on previous research, this study utilised a 2.4 (6%) point change in self-efficacy scores as a MCID.
results40 patients (82%) completed follow-up surveys at 12 months. After regression adjustment for those factors known to impact recovery from critical care, there was a 0.07-0.16 point improvement in quality of life for those patients who took part in the intervention compared to historical controls from the same institution, depending on specific regression strategy used. Self-efficacy scores increased by 2.5 points (6.25%) over the duration of the five week programme (p = 0.003), and was sustained at one year post intervention. In the year following ICU, 15 InS:PIRE patients returned to employment or volunteering roles (88%) compared with 11 (46%) in the historical control group (p = 0.15). CONCLUSIONS AND RELEVANCE: This historical control study suggests that a complex intervention may improve quality of life and self-efficacy in survivors of ICU. A larger, multi-centre study is needed to investigate this intervention further.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.