ArticlePloS one2017
Identification and characterization of novel cecropins from the Oxysternon conspicillatum neotropic dung beetle.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Inhibitory Effects of Oxysterlina 3, Satanin 1, and Curvicin Cecropins on the Growth and stx2 Gene Expression of Shiga Toxin-Producing Escherichia coli (STEC).Current microbiology · 2026Article
- Antimicrobial Peptides Act-6 and Act 8-20 Derived from Scarabaeidae Cecropins Exhibit Differential Antifungal Activity.Journal of fungi (Basel, Switzerland) · 2025Article
- Evaluation of Satanin 1 as a potential antifungal antimicrobial peptide to treat Malassezia infections.Scientific reports · 2025Article
- A novel broad-spectrum antibacterial and anti-malarial Anopheles gambiae Cecropin promotes microbial clearance during pupation.PLoS pathogens · 2024Article
- Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin andBiomolecules · 2024Article
- Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges.Antibiotics (Basel, Switzerland) · 2023Review
- Article
- Cloning, recombinant expression, purification, and functional characterization of AGAAN antibacterial peptide.3 Biotech · 2023Article
- New Insect Host Defense Peptides (HDP) From Dung Beetle (Coleoptera: Scarabaeidae) Transcriptomes.Journal of insect science (Online) · 2021Article
- Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex.Frontiers in microbiology · 2021Review
- Antimicrobial Peptides Derived From Insects Offer a Novel Therapeutic Option to Combat Biofilm: A Review.Frontiers in microbiology · 2021Review
- The biology of Megalolaelaps colossus (Acari: Dermanyssina).Experimental & applied acarology · 2020Article
- Insect Cecropins, Antimicrobial Peptides with Potential Therapeutic Applications.International journal of molecular sciences · 2019Review
- Characterization of the anti-Staphylococcus aureus fraction from Penthorum chinense Pursh stems.BMC complementary and alternative medicine · 2019Article
- Toward insights on determining factors for high activity in antimicrobial peptides via machine learning.PeerJ · 2019Article
- Antimicrobial and Antibiofilm Activity of a Recombinant Fragment of β-Thymosin of Sea UrchinMarine drugs · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dung beetles are exposed to a complex microbiological ecosystem during their life cycle. Characterization of novel host-defense peptides (HDP) is essential to understanding the host innate immune response in insects. It constitutes a promising alternative to look for new therapeutic agents against pathogenic microbes. We identified four new HDP, Oxysterlins 1, 2, 3, and 4 from the transcriptome of the Oxysternon conspicillatum dung beetle. These HDP display a highly conserved signal peptide and a mature peptide, characterized by an overall positive charge (cationic) (pI: 10.23-11.49), a hydrophobic ratio (ΦH: 35-41), and amphipathicity. Oxysterlins 1, 2, and 3 have a linear α-helix structure, whilst Oxysterlin 4 has a mixture of both α-helix and β-sheet structures without disulfide bonds through bioinformatics prediction and circular dichroism. Oxysterlins are part of the cecropin family group in an exclusive clade related to beetle cecropins. They have predominant antimicrobial activity against Gram-negative bacteria, including multidrug resistant strains (3.12-50 μg/mL) measured by plate microdilution. Their kinetics, in a time-killing curve showed concentration-dependent bactericidal activity. Furthermore, these HDP have low toxicity against human erythrocytes (62.5-500 μg/mL) and Vero cells (250-500 μg/mL). This article describes new HDP of the cecropin family from the Oxysternon conspicillatum dung beetle, with antimicrobial activity against multidrug resistant bacteria and low toxicity.
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