Evidence map›Paper›PMID 29186115›Full record

ArticleNature2017

A transfer-RNA-derived small RNA regulates ribosome biogenesis.

Hak Kyun Kim, Gabriele Fuchs, Shengchun Wang, Wei Wei, Yue Zhang, Hyesuk Park, Biswajoy Roy-Chaudhuri, Pan Li, Jianpeng Xu, Kirk Chu and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 378 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
378citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

378 citing papers in PubMed, 1 synthesis or guideline pooled it, 623 citations in OpenAlex.

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318 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Hak Kyun KimDepartment of Pediatrics, Stanford University, Stanford, California 94305, USA.
Gabriele FuchsDepartment of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA.
Shengchun WangDepartment of Pediatrics, Stanford University, Stanford, California 94305, USA.
Wei WeiAsian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA.
Yue ZhangDepartment of Pediatrics, Stanford University, Stanford, California 94305, USA.
Hyesuk ParkDepartment of Pediatrics, Stanford University, Stanford, California 94305, USA.
Biswajoy Roy-ChaudhuriDepartment of Pediatrics, Stanford University, Stanford, California 94305, USA.
Pan LiMOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology, Center for Synthetic and Systems Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Jianpeng XuDepartment of Pediatrics, Stanford University, Stanford, California 94305, USA.
Kirk ChuDepartment of Pediatrics, Stanford University, Stanford, California 94305, USA.
Feijie ZhangDepartment of Pediatrics, Stanford University, Stanford, California 94305, USA.
Mei-Sze ChuaAsian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA.
Samuel SoAsian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA.
Qiangfeng Cliff ZhangMOE Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology, Center for Synthetic and Systems Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Peter SarnowDepartment of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA.
Mark A KayDepartment of Pediatrics, Stanford University, Stanford, California 94305, USA.
Stanford University · USCenter for Life Sciences · CNTsinghua University · CN

Funding

RNAi for the Treatment of Viral HepatitisR01AI071068 · NIAID · STANFORD UNIVERSITY · PI KAY, MARK A · 2006 to 2020
$6.7M
The role of small RNA derived tRNAs in gene regulation: Mechanism and Therapeutic ApplicationsR01DK114483 · NIDDK · STANFORD UNIVERSITY · PI KAY, MARK A · 2017 to 2020
$2.0M
NIAID NIH HHS R01 AI071068NIDDK NIH HHS R01 DK114483
6 · The paper itself

Abstract

Transfer-RNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments) are an abundant class of small non-coding RNAs whose biological roles are not well understood. Here we show that inhibition of a specific tsRNA, LeuCAG3'tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-derived orthotopic hepatocellular carcinoma model in mice. This tsRNA binds at least two ribosomal protein mRNAs (RPS28 and RPS15) to enhance their translation. A decrease in translation of RPS28 mRNA blocks pre-18S ribosomal RNA processing, resulting in a reduction in the number of 40S ribosomal subunits. These data establish a post-transcriptional mechanism that can fine-tune gene expression during different physiological states and provide a potential new target for treating cancer.

Indexed as

AnimalsApoptosisBase PairingBase SequenceCarcinoma, HepatocellularCell ProliferationCell SurvivalFemaleHCT116 CellsHEK293 CellsHeLa CellsHumansLiver NeoplasmsMaleMiceOligonucleotides, AntisenseOligonucleotides, AntisenseRibosomal ProteinsRNA, MessengerRNA, Ribosomal, 18SRNA, Small UntranslatedRNA, Transfer, Leu

Identifiers

PMID29186115
PMCPMC6066594
OpenAlexW2769036773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.