Evidence map›Paper›PMID 29186111›Full record

ArticleNature2017

Genetic diversity of the African malaria vector Anopheles gambiae.

Anopheles gambiae 1000 Genomes Consortium, Data analysis group, Partner working group, Sample collections—Angola:, Burkina Faso:, Cameroon:, Gabon:, Guinea:, Guinea-Bissau:, Kenya: and 5 more

Abstract read
In one paragraph

Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 243 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
243citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

243 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. Coalescence and translation: A language model for population genetics.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  18. Population genomics ofScience (New York, N.Y.) · 2026
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183 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anopheles gambiae 1000 Genomes Consortium
Data analysis group
Partner working group
Sample collections—Angola:
Burkina Faso:
Cameroon:
Gabon:
Guinea:
Guinea-Bissau:
Kenya:
Uganda:
Crosses:
Sequencing and data production
Web application development
Project coordination

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY, MOSES Robert KAMYA · 2010 to 2026
$29.3M
Development of a Field Applicable Screening Tool (FAST) kit for detecting resistaR01AI082734 · NIAID · TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE · PI DONNELLY, MARTIN JAMES · 2009 to 2013
$1.6M
POPULATION GENOMICS OF ADAPTATIONR01GM117241 · NIGMS · UNIVERSITY OF OREGON · PI KERN, ANDREW D · 2017 to 2020
$1.2M
TARGETING OF LIPOSOMES TO TUMOR CELLSK04CA000718 · NCI · UNIVERSITY OF TENNESSEE KNOXVILLE · PI HUANG, LEAF · 1985 to 1985
–
Medical Research Council G0600718Medical Research Council G1002624Medical Research Council G1100339Medical Research Council MR/M006212/1NIAID NIH HHS R01 AI082734NIAID NIH HHS U19 AI089674NIGMS NIH HHS R01 GM117241Wellcome Trust 090532/Z/09/ZWellcome Trust 090770/Z/09/ZWellcome Trust 098051Wellcome Trust 204911/Z/16/Z
6 · The paper itself

Abstract

The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.

Indexed as

AfricaAnimalsAnophelesFemaleGene Drive TechnologyGene FlowGenetic VariationGenome, InsectInsecticide ResistanceMalariaMaleMosquito ControlMosquito VectorsPolymorphism, Single NucleotidePopulation DensityX Chromosome

Identifiers

PMID29186111
PMCPMC6026373

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.