Evidence map›Paper›PMID 29186109›Full record

ArticleMucosal immunology2018

Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis.

B M Wittig, R Sabat, P Holzlöhner, E Witte-Händel, K Heilmann, K Witte, J Triebus, A Tzankov, J D Laman, B Bokemeyer and 8 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Emerging Pathological Engagement of Ferroptosis in Gut Diseases.Oxidative medicine and cellular longevity · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

B M WittigMedical Clinic 1 (Gastroenterology/Infectiology/Rheumatology), University Medicine Charité, Berlin, Germany.
R SabatInterdisciplinary Group of Molecular Immunopathology and Psoriasis Research and Treatment Center, Dermatology/Medical Immunology, University Medicine Charité, Berlin, Germany.
P HolzlöhnerMedical Clinic 1 (Gastroenterology/Infectiology/Rheumatology), University Medicine Charité, Berlin, Germany.
E Witte-HändelInterdisciplinary Group of Molecular Immunopathology and Psoriasis Research and Treatment Center, Dermatology/Medical Immunology, University Medicine Charité, Berlin, Germany.
K HeilmannMedical Clinic 1 (Gastroenterology/Infectiology/Rheumatology), University Medicine Charité, Berlin, Germany.
K WitteInterdisciplinary Group of Molecular Immunopathology and Psoriasis Research and Treatment Center, Dermatology/Medical Immunology, University Medicine Charité, Berlin, Germany.
J TriebusInterdisciplinary Group of Molecular Immunopathology and Psoriasis Research and Treatment Center, Dermatology/Medical Immunology, University Medicine Charité, Berlin, Germany.
A TzankovInstitute of Pathology, University Hospital Basel, Basel, Switzerland.
J D LamanDepartment of Neuroscience, University Medical Center Groningen, Groningen, The Netherlands.
B BokemeyerGastroenterology Practice, Minden, Germany.
L TerraccianoInstitute of Pathology, University Hospital Basel, Basel, Switzerland.
C SchwärzlerFederal Polytechnic University Lausanne (Flow Cytometry Core Facility), Lausanne, Switzerland.
H KohlerFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
R VolkmerInstitute for Medical Immunology, University Medicine Charité, Berlin, Germany.
C LoddenkemperInstitute of Pathology, University Medicine Charité, Berlin, Germany.
K WolkInterdisciplinary Group of Molecular Immunopathology and Psoriasis Research and Treatment Center, Dermatology/Medical Immunology, University Medicine Charité, Berlin, Germany.
U HoffmannMedical Clinic 1 (Gastroenterology/Infectiology/Rheumatology), University Medicine Charité, Berlin, Germany.
U GünthertInstitute of Pathology, University Hospital Basel, Basel, Switzerland.
Charité - Universitätsmedizin Berlin · DEUniversity Hospital of Basel · CHÉcole Polytechnique Fédérale de Lausanne · CHFriedrich Miescher Institute · CHJohannes Wesling Klinikum Minden · DEUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD44 is a transmembrane molecule appearing in numerous isoforms generated by insertions of alternatively spliced variant exons (CD44v) and having various binding partners. CD44v7 on T cells was proposed to promote colitis by preventing T-cell apoptosis. Here we demonstrate that Cd44v7-deficient T cells - like Cd44 wild-type (Cd44

Indexed as

AdultAlternative SplicingAnimalsCells, CulturedCoculture TechniquesColitisCrohn DiseaseCytokinesDisease Models, AnimalExonsFemaleForkhead Transcription FactorsHumansHyaluronan ReceptorsInflammation MediatorsMacrophagesCytokinesForkhead Transcription FactorsFoxp3 protein, mouseHyaluronan ReceptorsInflammation MediatorsOsteopontin

Identifiers

PMID29186109
OpenAlexW2768674511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.