Evidence map›Paper›PMID 29186108›Full record

ArticleMucosal immunology2018

IL-15 supports the generation of protective lung-resident memory CD4 T cells.

T M Strutt, K Dhume, C M Finn, J H Hwang, C Castonguay, S L Swain, K K McKinstry

Open access · bronzeAbstract read
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. CD4Immunology and cell biology · 2025
    Review
  5. Article
  6. PLZF-expressing CD4Cell communication and signaling : CCS · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. A tumor-conditional IL-15 safely synergizes with immunotherapy to enhance antitumor immune responses.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

T M StruttDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA.
K DhumeDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA.
C M FinnDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA.
J H HwangDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA.
C CastonguayDepartment of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
S L SwainDepartment of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
K K McKinstryDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA.
University of Central Florida · USUniversity of Massachusetts Chan Medical School · US

Funding

T cell memory to TB in the lungP01AI046530 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 1999 to 2013
$22.2M
T cell and transgenic core U19AI109858 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUSEBY, ERIC S · 2014 to 2018
$11.9M
Defining a memory checkpoint for CD4 T cellsR01AI118820 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 2015 to 2019
$2.1M
Memory CD4 T Cell Regulation of Innate Lymphoid CellsR21AI117457 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI STRUTT, TARA MARLENE · 2016 to 2017
$379k
NIAID NIH HHS P01 AI046530NIAID NIH HHS R01 AI118820NIAID NIH HHS R21 AI117457NIAID NIH HHS U19 AI109858
6 · The paper itself

Abstract

Tissue-resident memory T cells (T

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCells, CulturedDendritic CellsImmunologic MemoryInflammation MediatorsInterleukin-15Interleukin-2LungLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutOrthomyxoviridaeInflammation MediatorsInterleukin-15Interleukin-2

Identifiers

PMID29186108
PMCPMC5975122
OpenAlexW2768160816

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.