ArticlePediatric research2018
Late preterm prelabor rupture of fetal membranes: fetal inflammatory response and neonatal outcome.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Placental pathologic score 1-2 subclinical abnormalities and early neonatal clinical indicators in term infants: a retrospective study.American journal of translational research · 2026Article
- The Predictive Value of Umbilical Cord Interleukin-6: Implications for Neonatal Care-A Narrative Review of Current Evidence and Future Perspectives.Life (Basel, Switzerland) · 2025Review
- Interleukin 6 for the Prediction of Chorioamnionitis: A Systematic Review and Meta-Analysis.Biomedicines · 2025Review
- Quantification of intra-amniotic inflammation in late preterm prelabour rupture of membranes.Scientific reports · 2025Article
- Diagnostic Value of Umbilical Cord Blood Interleukin-6 Level in Premature Infants with Early-Onset Sepsis.Children (Basel, Switzerland) · 2025Article
- Frontiers in the Etiology and Treatment of Preterm Premature Rupture of Membrane: From Molecular Mechanisms to Innovative Therapeutic Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Article
- Does the Amniotic Fluid of Mice Contain a Viable Microbiota?Frontiers in immunology · 2022Article
- Review
- Article
- Article
- Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes.Scientific reports · 2020Article
- The alarmin interleukin-1α causes preterm birth through the NLRP3 inflammasome.Molecular human reproduction · 2020Article
- A new rapid bedside test to diagnose and monitor intraamniotic inflammation in preterm PROM using transcervically collected fluid.American journal of obstetrics and gynecology · 2020Article
- A multicentre observational study on neonates exposed to SARS-CoV-2 in China: the Neo-SARS-CoV-2 Study protocol.BMJ open · 2020Observational
- Antibiotic administration reduces the rate of intraamniotic inflammation in preterm prelabor rupture of the membranes.American journal of obstetrics and gynecology · 2020Article
- Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes.Journal of perinatal medicine · 2020Article
- Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes.Journal of perinatal medicine · 2020Article
- Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease.Frontiers in immunology · 2020Review
- Prevention, Reduction and Repair of Brain Injury of the Preterm Infant.Frontiers in physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundTo characterize the influence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI) on the intensity of the fetal inflammatory response and the association between the presence of the fetal inflammatory response syndrome (FIRS) and short-term neonatal morbidity in the preterm prelabor rupture of membranes (PPROM) between the gestational ages of 34 and 37 weeks.MethodsOne hundred and fifty-nine women were included in the study. The umbilical cord blood interleukin (IL)-6 concentrations were determined using enzyme-linked immunosorbent assay kits. FIRS was defined based on the umbilical cord blood IL-6 concentration and the presence of funisitis and/or chorionic plate vasculitis.ResultsWomen with both MIAC and IAI had the highest median umbilical cord blood IL-6 concentrations and highest rates of FIRS. Women with FIRS had the higher rates of early-onset sepsis and intraventricular hemorrhage grades I and II when FIRS was characterized based on the umbilical cord blood IL-6 concentrations and the histopathological findings.ConclusionThe presence of both MIAC and IAI was associated with a higher fetal inflammatory response and a higher rate of FIRS. Different aspects of short-term neonatal morbidity were related to FIRS when defined by umbilical cord blood IL-6 concentrations and the histopathology of the placenta.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.