ReviewInternational journal of molecular sciences2017
Telomeres, Aging and Exercise: Guilty by Association?
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical activity, cardiorespiratory fitness and risk of cutaneous malignant melanoma: Systematic review and meta-analysis.PloS one · 2018Pooled it
- Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study.Journal of advanced research · 2026Article
- Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis.Aging · 2025Review
- Relationship between physical activity and DNA methylation-predicted epigenetic clocks.npj aging · 2025Article
- Synthesis and Molecular Dynamic Simulation of Novel Cationic and Non-cationic Pyrimidine Derivatives as Potential G-quadruplex-ligands.Anti-cancer agents in medicinal chemistry · 2024Article
- Healthy Lifestyle Behaviors and Biological Aging in the U.S. National Health and Nutrition Examination Surveys 1999-2018.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Telomere Attrition in Chronic Kidney Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks.Life (Basel, Switzerland) · 2022Review
- Protective Effects of Exercise Become Especially Important for the Aging Immune System in The Covid-19 Era.Aging and disease · 2022Review
- Role of the mtDNA Mutations and Mitophagy in Inflammaging.International journal of molecular sciences · 2022Review
- Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies.Journal of clinical medicine · 2021Review
- Epigenetic dysregulation in cardiovascular aging and disease.The journal of cardiovascular aging · 2021Article
- Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging.Trends in molecular medicine · 2020Review
- Moderate levels of physical fitness maintain telomere length in non-senescent T CD8+ cells of aged men.Clinics (Sao Paulo, Brazil) · 2020Article
- Developments in molecular epidemiology of aging.Emerging topics in life sciences · 2019Article
- Is Telomere Length a Biomarker of Adaptive Response in Space? Curious Findings from NASA and Residents of High Background Radiation Areas.Journal of biomedical physics & engineering · 2019Article
- ShRNA-mediated silencing of hTERT promote apoptosis and senescence in human ovarian cancer cells.Translational cancer research · 2019Article
- Review
- Vascular Senescence in Cardiovascular and Metabolic Diseases.Frontiers in cardiovascular medicine · 2018Article
- Beginning at the ends: telomeres and human disease.F1000Research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres are repetitive tandem DNA sequences that cap chromosomal ends protecting genomic DNA from enzymatic degradation. Telomeres progressively shorten with cellular replication and are therefore assumed to correlate with biological and chronological age. An expanding body of evidence suggests (i) a predictable inverse association between telomere length, aging and age-related diseases and (ii) a positive association between physical activity and telomere length. Both hypotheses have garnered tremendous research attention and broad consensus; however, the evidence for each proposition is inconsistent and equivocal at best. Telomere length does not meet the basic criteria for an aging biomarker and at least 50% of key studies fail to find associations with physical activity. In this review, we address the evidence in support and refutation of the putative associations between telomere length, aging and physical activity. We finish with a brief review of plausible mechanisms and potential future research directions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.