Evidence map›Paper›PMID 29186042›Full record

ArticleMolecules (Basel, Switzerland)2017

2-Substituted Aniline as a Simple Scaffold for LuxR-Regulated QS Modulation.

Sizhe Li, Julien Wawrzyniak, Yves Queneau, Laurent Soulère

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sizhe LiUniv Lyon, INSA LYON, Université Lyon 1, CPE Lyon, UMR 5246, CNRS, ICBMS, Bât. J. Verne, 20 Avenue A. Einstein, F-69621 Villeurbanne, France. sizhe.li@insa-lyon.fr.
Julien WawrzyniakUniv Lyon, INSA Lyon, Université Lyon 1, UMR 5240, CNRS, MAP, 10 rue Raphaël Dubois, F-69622 Villeurbanne, France. julien.wzk@gmail.com.
Yves QueneauUniv Lyon, INSA LYON, Université Lyon 1, CPE Lyon, UMR 5246, CNRS, ICBMS, Bât. J. Verne, 20 Avenue A. Einstein, F-69621 Villeurbanne, France. yves.queneau@insa-lyon.fr.
Laurent SoulèreUniv Lyon, INSA LYON, Université Lyon 1, CPE Lyon, UMR 5246, CNRS, ICBMS, Bât. J. Verne, 20 Avenue A. Einstein, F-69621 Villeurbanne, France. laurent.soulere@insa-lyon.fr.
Centre National de la Recherche Scientifique · FRInstitut de Chimie et Biochimie Moléculaires et Supramoléculaires · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of the 2-substituted aniline motif to serve as a scaffold for designing potential LuxR-regulated quorum sensing (QS) modulators has been investigated, using docking experiments and biological evaluation of a series of 15 specially synthesized compounds. Aniline, 2-acetyl-aniline and 2-nitroaniline were considered, as well as their

Indexed as

Quorum SensingAcylationAniline CompoundsBinding SitesHydrogen BondingModels, MolecularMolecular ConformationProtein BindingRepressor ProteinsStructure-Activity RelationshipTrans-ActivatorsanilineAniline CompoundsLuxR autoinducer binding proteinsRepressor ProteinsTrans-Activators2-nitroaniline scaffoldantagonistsmolecular dockingquorum sensing

Identifiers

PMID29186042
PMCPMC6149922
OpenAlexW2774066441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.