Evidence map›Paper›PMID 29185534›Full record

ArticleNeurology. Clinical practice2017

Mild brain injury and anticoagulants: Less is enough.

Laura Campiglio, Francesca Bianchi, Claudio Cattalini, Daniela Belvedere, Chiara Emilia Rosci, Chiara Livia Casellato, Manuela Secchi, Maria Cristina Saetti, Elena Baratelli, Alessandro Innocenti and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Neurology. Clinical practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  8. Observational
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Laura CampiglioIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Francesca BianchiIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Claudio CattaliniIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Daniela BelvedereIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Chiara Emilia RosciIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Chiara Livia CasellatoIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Manuela SecchiIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Maria Cristina SaettiIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Elena BaratelliIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Alessandro InnocentiIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Ilaria CovaIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Chiara GambiniIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Luca RomanoIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Gaia OggioniIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Rossella PaganiIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Marco GardinaliIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
Alberto PrioriIII Neurological Clinic, Department of Health Sciences (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), Neurology Unit (LC, FB, CC, DB, CER, CLC, MS, MCS, EB, AI, IC, CG, LR, GO, RP, AP), and Emergency Unit (MG), San Paolo University Hospital, ASST Santi Paolo e Carlo, Milan University; Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan; and Fondazione IRCCS Ca' Granda (AP), Milan, Italy.
University of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the higher theoretical risk of traumatic intracranial hemorrhage (ICH) in anticoagulated patients with mild head injury, the value of sequential head CT scans to identify bleeding remains controversial. This study evaluated the utility of 2 sequential CT scans at a 48-hour interval (CT1 and CT2) in patients with mild head trauma (Glasgow Coma Scale 13-15) taking oral anticoagulants.

methodsWe retrospectively evaluated the clinical records of all patients on chronic anticoagulation treatment admitted to the emergency department for mild head injury.

resultsA total of 344 patients were included, and 337 (97.9%) had a negative CT1. CT2 was performed on 284 of the 337 patients with a negative CT1 and was positive in 4 patients (1.4%), but none of the patients developed concomitant neurologic worsening or required neurosurgery.

conclusionsSystematic routine use of a second CT scan in mild head trauma in patients taking anticoagulants is expensive and clinically unnecessary.

Identifiers

PMID29185534
PMCPMC5648198
OpenAlexW2681770368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.