ArticleNature communications2017
Intracellular localization of nanoparticle dimers by chirality reversal.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Plasmon-Exciton Strong Coupling in Low-Dimensional Materials: From Fundamentals to Hybrid Nanophotonic Platforms.Nanomaterials (Basel, Switzerland) · 2025Review
- Review
- Inducing Efficient and Multiwavelength Circularly Polarized Emission From Perovskite Nanocrystals Using Chiral Metasurfaces.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Plasmonic nanoparticle sensors: current progress, challenges, and future prospects.Nanoscale horizons · 2024Review
- Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo.Light, science & applications · 2024Article
- Synthesis and Characterization of Gold Chiral Nanoparticles Functionalized by a Chiral Drug.Nanomaterials (Basel, Switzerland) · 2023Article
- Circularly Polarized Light-Enabled Chiral Nanomaterials: From Fabrication to Application.Nano-micro letters · 2023Review
- Gold-Nanoparticle-Based Chiral Plasmonic Nanostructures and Their Biomedical Applications.Biosensors · 2022Review
- In situ analysis of nanoparticle soft corona and dynamic evolution.Nature communications · 2022Article
- Light Extinction by Agglomerates of Gold Nanoparticles: A Plasmon Ruler for Sub-10 nm Interparticle Distances.Analytical chemistry · 2022Article
- Chirality at nanoscale for bioscience.Chemical science · 2022Review
- Self-assembled inorganic chiral superstructures.Nature reviews. Chemistry · 2022Review
- Hierarchical self-assembly into chiral nanostructures.Chemical science · 2022Review
- Influence of the chirality of carbon nanodots on their interaction with proteins and cells.Nature communications · 2021Article
- Recent developments in the chiroptical properties of chiral plasmonic gold nanostructures: bioanalytical applications.Mikrochimica acta · 2021Review
- l-cysteine-modified chiral gold nanoparticles promote periodontal tissue regeneration.Bioactive materials · 2021Article
- X-ray-Based Techniques to Study the Nano-Bio Interface.ACS nano · 2021Article
- Shining light on chiral inorganic nanomaterials for biological issues.Theranostics · 2021Review
- Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies.Nature biomedical engineering · 2021Article
- The Red Color of Life Transformed - Synthetic Advances and Emerging Applications of Protoporphyrin IX in Chemical Biology.European journal of organic chemistry · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intra- and extracellular positioning of plasmonic nanoparticles (NPs) can dramatically alter their curative/diagnostic abilities and medical outcomes. However, the inability of common spectroscopic identifiers to register the events of transmembrane transport denies their intracellular vs. extracellular localization even for cell cultures. Here we show that the chiroptical activity of DNA-bridged NP dimers allows one to follow the process of internalization of the particles by the mammalian cells and to distinguish their extra- vs intra-cellular localizations by real-time spectroscopy in ensemble. Circular dichroism peaks in the visible range change from negative to positive during transmembrane transport. The chirality reversal is associated with a spontaneous twisting motion around the DNA bridge caused by the large change in electrostatic repulsion between NPs when the dimers move from interstitial fluid to cytosol. This finding opens the door for spectroscopic targeting of plasmonic nanodrugs and quantitative assessment of nanoscale interactions. The efficacy of dichroic targeting of chiral nanostructures for biomedical applications is exemplified here as photodynamic therapy of malignancies. The efficacy of cervical cancer cell elimination was drastically increased when circular polarization of incident photons matched to the preferential absorption of dimers localized inside the cancer cells, which is associated with the increased generation of reactive oxygen species and their preferential intracellular localization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.