Evidence map›Paper›PMID 29185359›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2018

Gualou Guizhi decoction reverses brain damage with cerebral ischemic stroke, multi-component directed multi-target to screen calcium-overload inhibitors using combination of molecular docking and protein-protein docking.

Juan Hu, Wen-Sheng Pang, Jing Han, Kuan Zhang, Ji-Zhou Zhang, Li-Dian Chen

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. The Effect of Probiotics in Stroke Treatment.Evidence-based complementary and alternative medicine : eCAM · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Juan Hua Fujian Academy of Traditional Chinese Medicine , Fuzhou , PR China.
Wen-Sheng Pangb School of Rehabilitation Medicine , Fujian University of Traditional Chinese Medicine , Fuzhou , PR China.
Jing Hana Fujian Academy of Traditional Chinese Medicine , Fuzhou , PR China.
Kuan Zhangc The Second People's Hospital of Fujian Province , Fuzhou , PR China.
Ji-Zhou Zhanga Fujian Academy of Traditional Chinese Medicine , Fuzhou , PR China.
Li-Dian Chena Fujian Academy of Traditional Chinese Medicine , Fuzhou , PR China.
Fujian University of Traditional Chinese Medicine · CNFuzhou Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is a disease of the leading causes of mortality and disability across the world, but the benefits of drugs curative effects look less compelling, intracellular calcium overload is considered to be a key pathologic factor for ischemic stroke. Gualou Guizhi decoction (GLGZD), a classical Chinese medicine compound prescription, it has been used to human clinical therapy of sequela of cerebral ischemia stroke for 10 years. This work investigated the GLGZD improved prescription against intracellular calcium overload could decreased the concentration of [Ca

Indexed as

Molecular Docking SimulationAdministration, OralAnimalsBrain IschemiaCalciumDose-Response Relationship, DrugDrugs, Chinese HerbalProtein BindingRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSmall Molecule LibrariesStrokeStructure-Activity RelationshipTacrolimus Binding Protein 1ATrichosanthinCalciumDrugs, Chinese Herbalguizhi decoctionNR2B NMDA receptorReceptors, N-Methyl-D-AspartateSmall Molecule LibrariesTacrolimus Binding Protein 1ATrichosanthincalcium-overloadGualou Guizhi decoctioninhibitors screeningreverses brain damage

Identifiers

PMID29185359
PMCPMC6009878
OpenAlexW2770870214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.