ArticleJournal of biomedical optics2017
Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Ultradeformable Vesicles for Wound Healing: Ethosomes, Transferosomes, and Transethosomes in Topical Drug Delivery.Pharmaceutics · 2026Review
- Investigating the impact of different time delays between OCT signal and k-clock signal on the structural and vascular imaging in SS-OCT.Biomedical optics express · 2025Article
- Adaptive contour-tracking to aid wide-field swept-source optical coherence tomography imaging of large objects with uneven surface topology.Biomedical optics express · 2024Article
- High-speed, long-range and wide-field OCT for in vivo 3D imaging of the oral cavity achieved by a 600 kHz swept source laser.Biomedical optics express · 2024Article
- Visualization enhancement by PCA-based image fusion for skin burns assessment in polarization-sensitive OCT.Biomedical optics express · 2024Article
- Multispectral Imaging Analysis of Skin Lesions in Patients with Neurofibromatosis Type 1.Journal of clinical medicine · 2023Article
- Automated robot-assisted wide-field optical coherence tomography using structured light camera.Biomedical optics express · 2023Article
- Automated segmentation and quantification of calcified drusen in 3D swept source OCT imaging.Biomedical optics express · 2023Article
- Integrating a pressure sensor with an OCT handheld probe to facilitate imaging of microvascular information in skin tissue beds.Biomedical optics express · 2022Article
- Imaging human skin autograft integration with optical coherence tomography.Quantitative imaging in medicine and surgery · 2021Article
- Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography.Scientific reports · 2021Article
- Quantitative Analysis of the Choriocapillaris in Uveitis Using En Face Swept-Source Optical Coherence Tomography Angiography.American journal of ophthalmology · 2020Article
- Quantification of Choriocapillaris with Optical Coherence Tomography Angiography: A Comparison Study.American journal of ophthalmology · 2019Article
- Photoacoustic computed tomography of human extremities.Journal of biomedical optics · 2019Article
- Evaluating changes of blood flow in retina, choroid, and outer choroid in rats in response to elevated intraocular pressure by 1300 nm swept-source OCT.Microvascular research · 2019Article
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4 authors.
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Abstract
There is an increasing demand for imaging tools in clinical dermatology that can perform in vivo wide-field morphological and functional examination from surface to deep tissue regions at various skin sites of the human body. The conventional spectral-domain optical coherence tomography-based angiography (SD-OCTA) system is difficult to meet these requirements due to its fundamental limitations of the sensitivity roll-off, imaging range as well as imaging speed. To mitigate these issues, we demonstrate a swept-source OCTA (SS-OCTA) system by employing a swept source based on a vertical cavity surface-emitting laser. A series of comparisons between SS-OCTA and SD-OCTA are conducted. Benefiting from the high system sensitivity, long imaging range, and superior roll-off performance, the SS-OCTA system is demonstrated with better performance in imaging human skin than the SD-OCTA system. We show that the SS-OCTA permits remarkable deep visualization of both structure and vasculature (up to ∼2 mm penetration) with wide field of view capability (up to 18×18 mm2), enabling a more comprehensive assessment of the morphological features as well as functional blood vessel networks from the superficial epidermal to deep dermal layers. It is expected that the advantages of the SS-OCTA system will provide a ground for clinical translation, benefiting the existing dermatological practice.
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