Evidence map›Paper›PMID 29185266›Full record

ArticleJournal of gynecologic oncology2018

Are vaginal swabs comparable to cervical smears for human papillomavirus DNA testing?

Liselotte Coorevits, Ans Traen, Luc Bingé, Jo Van Dorpe, Marleen Praet, Jerina Boelens, Elizaveta Padalko

Registry-linked trialOpen access · diamondAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gynecologic oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05783167 (Self-collected Cervical Cancer Screening Samples for Detection of Human Papillomavirus in HIV-positive Women - a Pilot Study of Self-collected Vaginal and Urine Samples), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05783167 completednot on this mapstarted 2023, after this paper: background citation

Self-collected Cervical Cancer Screening Samples for Detection of Human Papillomavirus in HIV-positive Women - a Pilot Study of Self-collected Vaginal and Urine Samples

TypeobservationalSponsorUniversity of AarhusRan2023 to 2024Enrolled502ConditionsHIV Infections, HPV-Related Cervical Carcinoma, Cervical Cancer, Coinfection, HIVArmsSelf-sampling for HPV infection
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Liselotte CoorevitsDepartment of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.ORCID https://orcid.org/0000-0001-6455-2160
Ans TraenPasop vzw, Ghent, Belgium.ORCID https://orcid.org/0000-0002-6293-4656
Luc BingéPasop vzw, Ghent, Belgium.
Jo Van DorpeDepartment of Pathology, Ghent University and Ghent University Hospital, Ghent, Belgium.
Marleen PraetDepartment of Pathology, Ghent University and Ghent University Hospital, Ghent, Belgium.ORCID https://orcid.org/0000-0003-4522-6268
Jerina BoelensDepartment of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.
Elizaveta PadalkoDepartment of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.ORCID https://orcid.org/0000-0002-8101-6957
Ghent University Hospital · BEOrganic Waste Systems (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHuman papillomavirus (HPV) testing is widely incorporated into cervical cancer screening strategies. Current screening requires pelvic examination for cervical sampling, which may compromise participation. The acceptance could be raised by introducing testing on vaginal swabs. We explored the interchangeability of vaginal swabs and cervical smears for HPV testing, by means of a prospective study conducted in female sex workers (FSWs). Besides, we report on the occurrence of 32 different HPV genotypes in FSW with low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL).

methodsPaired physician-collected vaginal swabs and cervical smears from 303 FSW were tested for HPV using the Abbott RealTime High-Risk HPV assay. Cervical cytology was examined on cervical smears. In case of HSIL/LSIL cytological classification (n=52), both samples were genotyped using INNO-LiPa HPV Genotyping Extra II.

resultsThe overall prevalence of high-risk (HR)-HPV was 51%. In FSW with HSIL/LSIL cervical cytology, the sensitivity and specificity of vaginal samples for the detection of HR-HPV was 100% and 70% and for probable HR-HPV 100% and 91%. The mean number of genotypes identified in vaginal samples (mean=3.5; 95% confidence interval [CI]=2.8-4.2) was significantly higher than in cervical smear samples (mean=2.6; 95% CI=2.1-3.0) (p=0.001). The most frequently encountered HR-HPV genotypes were HPV16, 31, 51, and 52.

conclusionAs our study shows that vaginal swabs are equivalent to cervical smears for the detection of (probable) HR-HPV, vaginal swabs can be used for HPV testing in cervical cancer screening strategies. Given the acceptance of vaginal sampling, this finding offers an opportunity to boost screening coverage.

Indexed as

Human Papillomavirus DNA TestsMolecular TypingVaginal SmearsVirologyAdultCervix UteriDNA, ViralEarly Detection of CancerFemaleHumansMiddle AgedPapanicolaou TestPapillomaviridaePapillomavirus InfectionsSensitivity and SpecificitySex WorkersDNA, ViralChlamydia TrachomatisMycoplasma GenitaliumNeisseria GonorrhoeaePapillomaviridaeSexually Transmitted DiseasesTrichomonas Vaginalis

Identifiers

PMID29185266
PMCPMC5709534
OpenAlexW2766961757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.