Evidence map›Paper›PMID 29185130›Full record

ArticleImmunologic research2018

Increased lipid and protein oxidation and lowered anti-oxidant defenses in systemic lupus erythematosus are associated with severity of illness, autoimmunity, increased adhesion molecules, and Th1 and Th17 immune shift.

Bruna Miglioranza Scavuzzi, Andréa Name Colado Simão, Tatiana Mayumi Veiga Iriyoda, Marcell Alysson Batisti Lozovoy, Nicole Perugini Stadtlober, Lorena Flor da Rosa Franchi Santos, Tamires Flauzino, Fabiano Aparecido de Medeiros, Marcelo Cândido de Sá, Luana Consentin and 3 more

Abstract read
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In one paragraph

Article in Immunologic research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

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  4. Ferroptosis of T cell in inflammation and tumour immunity.Clinical and translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Bruna Miglioranza ScavuzziGraduate Program in Health Sciences-University of Londrina, Londrina, Brazil.
Andréa Name Colado SimãoDepartment of Pathology, Clinical Analysis and Toxicology-University of Londrina, Avenida Robert Koch, n 60. Londrina, Paraná, CEP: 86038-440, Brazil. deianame@yahoo.com.br.
Tatiana Mayumi Veiga IriyodaDepartment of Rheumatology-University of Londrina, Londrina, Brazil.
Marcell Alysson Batisti LozovoyDepartment of Pathology, Clinical Analysis and Toxicology-University of Londrina, Avenida Robert Koch, n 60. Londrina, Paraná, CEP: 86038-440, Brazil.
Nicole Perugini StadtloberGraduate Program in Pathology, Clinical Analysis and Toxicology-University of Londrina, Londrina, Brazil.
Lorena Flor da Rosa Franchi SantosGraduate Program in Pathology, Clinical Analysis and Toxicology-University of Londrina, Londrina, Brazil.
Tamires FlauzinoGraduate Program in Health Sciences-University of Londrina, Londrina, Brazil.
Fabiano Aparecido de MedeirosGraduate Program in Clinical and Laboratory Pathophysiology-University of Londrina, Londrina, Brazil.
Marcelo Cândido de SáGraduate Program in Clinical and Laboratory Pathophysiology-University of Londrina, Londrina, Brazil.
Luana ConsentinGraduate Program in Pathology, Clinical Analysis and Toxicology-University of Londrina, Londrina, Brazil.
Edna Maria Vissoci ReicheDepartment of Pathology, Clinical Analysis and Toxicology-University of Londrina, Avenida Robert Koch, n 60. Londrina, Paraná, CEP: 86038-440, Brazil.
Michael MaesIMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, VIC, Australia.
Isaias DichiDepartment of Internal Medicine-University of Londrina, Londrina, Brazil.
Universidade Estadual de Londrina · BRDeakin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated nitro-oxidative stress in patients with systemic lupus erythematosus (SLE) in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Two-hundred-four patients with SLE and 256 healthy volunteers were enrolled in this case-control study, which measured nitro-oxidative stress biomarkers, including lipid peroxides (LOOH), advanced oxidation protein products (AOPPs), nitric oxide metabolites (NO

Indexed as

AdultAdvanced Oxidation Protein ProductsAntibodies, AntinuclearBiomarkersCell Adhesion MoleculesFemaleHumansInflammationLipid PeroxidesLupus Erythematosus, SystemicMaleMiddle AgedNitric OxideNitrosative StressOxidative StressTh17 CellsAdvanced Oxidation Protein ProductsAntibodies, AntinuclearBiomarkersCell Adhesion MoleculesLipid PeroxidesNitric OxideAdhesion moleculesAnti-oxidantCytokinesReactive oxygen and nitrogen speciesSystemic lupus erythematosus

Identifiers

PMID29185130
OpenAlexW2769364279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.