ArticlePsychopharmacology2018
Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Long-term effects of alcohol consumption on cognitive function: a systematic review and dose-response analysis of evidence published between 2007 and 2018.Systematic reviews · 2020Pooled it
- Sex differences in alcohol use and perceptions of cognitive health in rural Uganda.BMC geriatrics · 2026Article
- Older adult solitary drinking: associations with subjective and objective cognitive functioning.Frontiers in aging neuroscience · 2025Article
- Lifestyle factors associated with episodic memory in middle-aged and older adults: evidence from a 9-year longitudinal study.BMC public health · 2024Article
- Alcohol Use Disorder and Dementia: A Review.Alcohol research : current reviews · 2024Review
- Association of alcohol use with memory decline in middle-aged and older Chinese: a longitudinal cohort study.BMC psychiatry · 2022Article
- Sociodemographic, Lifestyle, Physical, and Psychosocial Determinants of Cognitive Reserve.Journal of Alzheimer's disease : JAD · 2022Article
- Sex differences in cardiopulmonary effects of acute bromine exposure.Toxicology research · 2021Article
- Adult and adolescent C57BL/6J and DBA/2J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment.Behavioural brain research · 2021Article
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Alcohol's Unique Effects on Cognition in Women: A 2020 (Re)view to Envision Future Research and Treatment.Alcohol research : current reviews · 2020Review
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- Clarifying the neurobehavioral sequelae of moderate drinking lifestyles and acute alcohol effects with aging.International review of neurobiology · 2019Review
- Drinking patterns and adherence to "low-risk" guidelines among community-residing older adults.Drug and alcohol dependence · 2018Article
- Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study.Journal of aging and healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleThe beneficial effects of moderate alcohol may differ in aging men versus women.
objectivesCognitive and functional decline and neuropathology were investigated in a cohort of aging men and women with diverse alcohol histories.
methodsNon-demented (Clinical Dementia Rating (CDR) of ≤ 0.5 and a Mini-Mental State Examination (MMSE) score of > 24), autonomously living participants were tracked in longitudinal aging studies to examine self-report and objective tests of rates of decline in a cohort (n = 486) of octogenarians. Neurofibrillary tangles (NFTs; Braak stage) and neuritic plaques (NPs) were staged at autopsy in a subset of participants (n = 149) using current standard neuropathologic diagnostic criteria.
resultsModerate drinking men had an attenuated rate of decline compared to rare/never drinkers and women on the MMSE and CDR sum of boxes. In contrast, moderate drinking women had a reduced rate of decline only in the Logical Memory Delayed Recall Test (LMDR) compared to rare/never drinkers and men. Moderate alcohol consumption was associated with a reduction in the incidence of advanced (stages 5-6) Braak NFT stage in men (p < 0.05), with no effect in women.
conclusionsIn this cohort, men experienced a broader range of beneficial effects associated with alcohol. Alcohol's effects may differ in men and women in important ways that suggest a narrower beneficial window.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.