ReviewObstetrics & gynecology science2017
What is fetal programming?: a lifetime health is under the control of in utero health.
Review in Obstetrics & gynecology science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
172 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Decoding the molecular landscape of the placenta in maternal diabetes: a systematic review of high-throughput data.Journal of molecular endocrinology · 2026Pooled it
- Parental conditions, modifiable lifestyle factors, and first trimester growth and development: a systematic review.Human reproduction update · 2025Pooled it
- Prenatal air pollution exposure in relation to the telomere-mitochondrial axis of aging at birth: A systematic review.Environmental research · 2024Pooled it
- Effectiveness of pre-pregnancy lifestyle in preventing gestational diabetes mellitus-a systematic review and meta-analysis of 257,876 pregnancies.Nutrition & diabetes · 2023Pooled it
- Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts-A meta-analysis.Birth defects research · 2022Pooled it
- Mercury and Prenatal Growth: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis.Human reproduction update · 2020Pooled it
- Influence of Maternal Prepregnancy Obesity and Excessive Gestational Weight Gain on Maternal and Child Gastrointestinal Microbiome Composition: A Systematic Review.Biological research for nursing · 2020Pooled it
- Efficacy of a Personalized mHealth App in Improving Micronutrient Supplement Use Among Pregnant Women in Karachi, Pakistan: Parallel-Group Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- A Rapid Scoping Review of Nutritional Management of Beef Cows and Pre-Weaning Calves and the Occurrence of Bovine Respiratory Disease in Pre- and Post-Weaning Calves in North America.Animals : an open access journal from MDPI · 2026Review
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- Gestational Diabetes Mellitus Across the Perinatal Continuum: A Narrative Review of Woman-Centered, Holistic Care Models.Healthcare (Basel, Switzerland) · 2026Review
- Effect of Prenatal Vitamin D and Selenium Supplementation on Minipuberty in Male Offspring of Women with Autoimmune Thyroiditis.Nutrients · 2026Article
- Impact of Maternal Euthyroid Autoimmune Thyroiditis on Minipuberty in Female Offspring.Nutrients · 2026Article
- Longitudinal patterns of urinary biomarkers of placental and renal function in pregnancy and associations with early pregnancy exposure to phthalates and replacements.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- Biopsychosocial factors during pregnancy and their implications for autism spectrum disorder: a scoping review.BMC pediatrics · 2026Article
- The Future of Epigenetics: Emerging Technologies and Clinical Applications.ACS pharmacology & translational science · 2026Review
- Patient advocacy group perspectives on treatment priorities and clinical trials for the rare neurodevelopmental condition, Prader-Willi syndrome.Orphanet journal of rare diseases · 2026Article
- Integrative metabolomics and proteomics reveal early cardiovascular risk signatures in PCOS female offspring.Journal of ovarian research · 2026Article
112 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "Barker hypothesis" postulates that a number of organ structures and associated functions undergo programming during embryonic and fetal life, which determines the set point of physiological and metabolic responses that carry into adulthood. Hence, any stimulus or insult at a critical period of embryonic and fetal development can result in developmental adaptations that produce permanent structural, physiological and metabolic changes, thereby predisposing an individual to cardiovascular, metabolic and endocrine disease in adult life. This article will provide evidence linking these diseases to fetal undernutrition and an overview of previous studies in this area as well as current advances in understanding the mechanism and the role of the placenta in fetal programming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.